- Carbonyl dihydrazone derivative, preparation method and applications thereof
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The invention relates to a carbonyl dihydrazone derivative represented by a chemical structural formula I, and a pharmaceutically acceptable salt thereof, a pharmaceutical composition and applicationsin preparation of influenza virus neuraminidase inhibitors, wherein the formula I is defined in the specification, and R is selected from hydroxyl, dihydroxyl, 2-hydroxyl-3-methoxy, 2-hydroxyl-4-methoxy, 2-hydroxyl-5-methoxy, 2-hydroxyl-6-methoxy, 3-hydroxyl-2-methoxy, 3-hydroxyl-4-methoxy, 3-hydroxyl-5-methoxy, 3-hydroxyl-6-methoxy, 4-hydroxyl-2-methoxy, 4-hydroxyl-3-methoxy, 4-hydroxy-3,5-dimethoxy, 2-hydroxy-3-ethoxy, 2-hydroxy-4-ethoxy, 2-hydroxy-5-ethoxy, 2-hydroxy-6-ethoxy, 3-hydroxy-2-ethoxy, 3-hydroxy-4-ethoxy, 3-hydroxy-5-ethoxy, 3-hydroxy-6-ethoxy, 4-hydroxy-2-ethoxy, 4-hydroxy-3-ethoxy, 4-hydroxy-3,5-diethoxy, trihydroxy and 4-hydroxy-3,5-dimethyl.
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Paragraph 0027; 0032-0038
(2020/04/02)
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- The photochromism, light harvesting and self-assembly activity of a multi-function Schiff-base compound based on the AIE effect
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Aggregation-induced emission (AIE) luminogens with photochromic properties show strong potential in molecular switches, photo-controllable materials, photo-patterning, etc. In this paper one Schiff-base compound 1 exhibited reversible photo-controllable c
- Chai, Jie,Wu, Yanbo,Yang, Binsheng,Liu, Bin
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supporting information
p. 4057 - 4064
(2018/04/26)
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- Green synthetic method for 1,5-disubstituted carbohydrazones
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A green synthetic method for 1,5-disubstituted carbohydrazones is described. The reaction of dimethyl carbonate with hydrazine hydrate first gave carbohydrazide, which further reacted with various aromatic aldehydes or aliphatic ketones under solvent-free conditions to efficiently afford 1,5-disubstituted carbohydrazone. This protocol has the advantages of using nontoxic dimethyl carbonate as starting material, no use of organic solvents, short reaction time, high yield, and simple workup procedure. Copyright Taylor & Francis Group, LLC.
- Li, Zheng,Zhu, Wei,Yu, Jinlan,Ma, Xuelin,Lu, Zhong,Xiao, Shuxiu
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p. 2613 - 2619
(2007/10/03)
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