- carba Nicotinamide Adenine Dinucleotide Phosphate: Robust Cofactor for Redox Biocatalysis
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Here we report a new robust nicotinamide dinucleotide phosphate cofactor analog (carba-NADP+) and its acceptance by many enzymes in the class of oxidoreductases. Replacing one ribose oxygen with a methylene group of the natural NADP+ was found to enhance stability dramatically. Decomposition experiments at moderate and high temperatures with the cofactors showed a drastic increase in half-life time at elevated temperatures since it significantly disfavors hydrolysis of the pyridinium-N?glycoside bond. Overall, more than 27 different oxidoreductases were successfully tested, and a thorough analytical characterization and comparison is given. The cofactor carba-NADP+ opens up the field of redox-biocatalysis under harsh conditions.
- D?ring, Manuel,Sieber, Volker,Simon, Robert C.,Tafertshofer, Georg,Zachos, Ioannis
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supporting information
p. 14701 - 14706
(2021/05/13)
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- Dehalogenative Deuteration of Unactivated Alkyl Halides Using D2O as the Deuterium Source
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The general dehalogenation of alkyl halides with zinc using D2O or H2O as a deuterium or hydrogen donor has been developed. The method provides an efficient and economic protocol for deuterium-labeled derivatives with a wide substrate scope under mild reaction conditions. Mechanistic studies indicated that a radical process is involved for the formation of organozinc intermediates. The facile hydrolysis of the organozinc intermediates provides the driving force for this transformation.
- Xia, Aiyou,Xie, Xin,Hu, Xiaoping,Xu, Wei,Liu, Yuanhong
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p. 13841 - 13857
(2019/10/17)
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- Ultrasmall Platinum Nanoparticles Supported Inside the Nanospaces of Periodic Mesoporous Organosilica with an Imidazolium Network: An Efficient Catalyst for the Aerobic Oxidation of Unactivated Alcohols in Water
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The imidazolium group inside the wall of a periodic mesoporous organosilica provides an excellent environment for the stabilization of ultrasmall Pt nanoparticles ((NP)@PMO-IL) with significant activity and recyclability in the selective aerobic oxidation of various alcohols in water at ambient pressure of oxygen. In particular, the catalyst exhibited high activity in the oxidation of unactivated primary alcohols and sterically encumbered secondary aliphatic alcohols, which remain challenging substrates for many catalytic aerobic protocols.
- Karimi, Babak,Naderi, Zahra,Khorasani, Mojtaba,Mirzaei, Hamid M.,Vali, Hojatollah
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p. 906 - 910
(2016/03/15)
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- Aqueous hydrogen peroxide and 2,4,4,6-tetrabromo-2,5-cyclohexadienone catalyst: An efficient mild ecofriendly cleaving reagent of thioacetals and thioketals
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A clean mild efficient dethioacetalization protocol is revealed utilizing a catalytic combination of 2,4,4,6-tetrabromo-2,5-cyclohexadienone (TBCHD) (20 mol%) with 30% hydrogen peroxide as a terminal oxidizer in aqueous acetonitrile at room temperature. High yields of carbonyl compounds without overoxidation for oxidation-prone aromatic and furyl aldehydes, simple work-up, use of cost-compatible readily accessible reagents, tolerance of a wide range of common functional and protecting groups including phenolic hydroxy, methylenedioxy, acetoxy, aromatic amino, carbon-carbon double bond, allyl, benzyl, TBDPS ethers, NHBoc, NHBz are the key attractive features of the method.
- Ganguly, Nemai C.,Nayek, Subhasis,Barik, Sujoy Kumar
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scheme or table
p. 251 - 256
(2012/03/11)
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- A DERIVATIVE OF AZEPINE AND ITS APPLICATION AS A SPECIFIC OPTICAL RESOLUTION AGENT
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The synthesis of (-)-(2S,trans)-perhydro-2-isopropyl-5-methyl-azepin-1-amine (1) and its use as a specific optical resolution agent of ketones is described.A method for the resolution of ketones and its application to three ketones is described.This method also involves the synthesis and separation of the pairs of hydrazones diastereomers followed by removal of hydrazines by hydrolysis to give the individual enantiomers of II, III and IV with high chiral purities.
- Fernandez, Franco,Perez, Cristina
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p. 2411 - 2417
(2007/10/02)
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