- Preparation method of compound 2,4,6-trifluorobenzylamine
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The invention discloses a preparation method of a compound 2,4,6-trifluorobenzylamine, and relates to the field of organic synthesis. According to the preparation method, pentachlorobenzonitrile is used as a starting raw material and is subjected to a fluorination reaction with a fluorinating agent in an organic solvent under the action of a catalyst to obtain 3,5-dichloro-2,4,6-trifluorobenzonitrile. The obtained 3,5-dichloro-2,4,6-trifluorobenzonitrile is added into water and reacts with zinc powder and mixed acid, and then reflux dechlorination is performed to obtain 2,4,6-trifluorobenzonitrile. The obtained 2,4,6-trifluorobenzonitrile is added into an organic solvent, and hydrogenation reduction is carried out under the action of an organic alkali and a catalyst to obtain the product 2,4,6-trifluorobenzylamine. The method has the advantages of short synthesis route, simple operation, mild reaction conditions, cheap and easily available raw materials and stable product quality, andis suitable for large-scale industrial production.
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Paragraph 0024; 0053; 0060
(2021/03/11)
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- PROCESS FOR PREPARATION OF HALOGENATED BENZYLAMINE AND INTERMEDIATES THEROF
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The present invention provides an improved process for the preparation of halogenated benzylamine having the formula I from halogenated benzonitriles, Formula I wherein, X1 is selected from group consisting of hydrogen, chloro or fluoro, provided atleast one X1 is chloro or fluoro.
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Page/Page column 16-17
(2020/08/13)
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- Preparation method of 2, 4, 6-trifluoromethylmethylamine (by machine translation)
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2, 4, 6 - Trifluorobenzaldehyde, is reacted with hydrogen under the action of a nickel catalyst to obtain the crude, trifluoromethylmethanamine, and the crude product, is obtained by reaction with hydrogen under the action of a nickel 2, 4, 6 - catalyst t
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Paragraph 0014-0016
(2020/04/17)
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- SYNTHESIS METHOD OF 2,4,6-TRIFLUOROBENZYLAMINE
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The disclosure provides a synthesis method of 2,4,6-trifluorobenzylamine, belonging to the technical field of chemical synthesis. The synthesis method is characterized by comprising the following steps: (1) allowing pentachlorobenzonitrile as a raw material to undergo fluoridation reaction with a fluoridation agent based on 2,4,6-trifluoro-3,5-dichlorobenzonitrile as a solvent to obtain 2,4,6-trifluoro-3,5-dichlorobenzonitrile; (2) hydrogenating the obtained 2,4,6-trifluoro-3,5-dichlorobenzonitrile with hydrogen in the presence of organic carboxylic acid, based, on palladium carbon as a catalyst to obtain 2,4,6-trifluoro-3,5-dichlorobenzylamine; and (3) hydrogenating the obtained 2,4,6-trifluoro-3,5-dichlorobenzylamine with hydrogen in a solvent in the presence of a catalyst to obtain 2,4,6-trifluorobenzylamine. The synthesis method has the advantages of low raw material cost, short reaction steps, high reaction yield, good product purity simple operation and the like, and is suitable for industrial production.
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- Preparation method of 2,4,6-trifluorobenzylamine
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The invention discloses a preparation method of 2,4,6-trifluorobenzylamine, and belongs to the technical field of chemical synthesis. The method comprises the following steps: (1), carrying out fluorination reaction on pentachloro benzonitrile and a fluorinating agent in a polar aprotic solvent at the presence of a catalyst so as to obtain 2,4,6-trifluoro-3,5-dichlorobenzonitrile; (2), carrying out hydrogen hydrogenation reduction on 2,4,6-trifluoro-3,5-dichlorobenzonitrile obtained in the step (1) by using palladium charcoal as a catalyst at the presence of organic carboxylic acid so as to obtain 2,4,6-trifluoro-3,5-dichlorobenzylamine; (3) carrying out hydrogen hydrogenation reduction on 2,4,6-trifluoro-3,5-dichlorobenzylamine obtained in the step (2) in the solvent under an effect of the catalyst so as to obtain 2,4,6-trifluorobenzylamine. The preparation method has the advantages of low costs of the raw materials, short reaction steps, high reaction yield, high purity of products and the like, and is suitable for industrial production and application.
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Paragraph 0096-0102
(2018/10/11)
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- Preparation method of 2,4,6-trifluorobenzylamine
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The invention provides a preparation method of 2,4,6-trifluorobenzylamine. The preparation method comprises the following steps: S1, by taking pentachloro benzonitrile as a starting material, adding the pentachloro benzonitrile into anhydrous potassium fluoride for fluorination reaction in a first organic solvent, thus obtaining 3,5-dichloro-2,4,6-trifluoro-cyanophenyl; S2a, adding the 3,5-dichloro-2,4,6-trifluoro-cyanophenyl prepared in the step S1 into a second organic solvent, adding organic alkali, feeding hydrogen, and carrying out dehydrochlorination reaction under the action of a firstcatalyst, thus obtaining 2,4,6-trifluoro-cyanophenyl serving as an intermediate; S3, adding the 2,4,6-trifluoro-cyanophenyl prepared in the step S2a into a third organic solvent, adding acid, feedinghydrogen, and reducing the 2,4,6-trifluoro-cyanophenyl serving as the intermediate through a cyanogroup under the action of a second catalyst, thus obtaining 2,4,6-trifluorobenzylamine. By the adoption of the technical scheme, the preparation method has the advantages that steps of a synthesis route are simple and short, conditions are mild, operation is simple and convenient, the raw materials are low in cost and readily available, and the production cost is low; the catalysts and solvents can be recycled for use, so that pollution is reduced; the preparation method is environmentally friendly and suitable for industrial large-scale production.
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Paragraph 0051; 0052; 0054; 0056; 0058; 0072; 0074; 0076
(2018/03/24)
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- Synthesis method of 2,4,6-trifluorobenzylamine
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The invention relates to a synthesis method of 2,4,6-trifluorobenzylamine and mainly aims to solve the technical problem of lack of effective synthesis methods. The synthesis method comprises the following steps: continuously filling hydrogen chloride gas into a mixed solution with 1,3,5-trifluorobenzene, paraformaldehyde, ,sulfuric acid and acetic acid mixed solution of zinc chloride to generatea compound I; performing reaction on the compound I with urotropine to generate a quaternary ammonium salt compound II; and hydrolyzing the compound II in methyl alcohol and concentrated hydrochloricacid to generate a target compound III. The synthesis method is simple and few in steps, simple to operate, low in production cost, high in product purity and high in yield, and is suitable for industrial production.
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- Preparation method of 2,4,6-trifluorobenzylamine
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The invention relates to a preparation method of 2,4,6-trifluorobenzylamine and belongs to the technical field of chemical industry, particularly to the field of chemical synthesis. According to the method, Raney-Ni is used as a catalyst, 2,4,6-trifluorobenzonitrile is reacted with hydrogen in methanol solution of ammonia under the action of the catalyst at the temperature of 25-120 DEG C, wherein a mass ratio of the 2,4,6-trifluorobenzonitrile, Raney-Ni, ammonia and methanol is 1:(0.05-0.1):(1.5-2):(10-12). The 2,4,6-trifluorobenzylamine prepared by using the method has high purity and yield, and the method produces little three wastes, is simple to perform and is easy to industrialize.
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Paragraph 0025; 0026
(2017/05/12)
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- A 2, 4, 6- three fluorine animal pens method for the preparation of amine compounds
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The invention relates to a preparation method of a 2,4,6-trifluoro-benzylamine compound. The preparation method comprises the following steps: taking 1,3,5-trifluoro-benzene as a raw material, and preparing 2,4,6-trifluoro-benzylamine through lithiation, formylation, reduction, halogenation and replacement reaction. The reaction condition is mild, the operability is high, the atom economy is high, the technology is simple and easy to realize industrialization, and the product is high in purity and stable in quality, so that the compound accords with the using requirement of being as an intermediate.
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Paragraph 0071; 0076; 0077
(2017/01/23)
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