214759-21-4 Usage
Description
2,4,6-Trifluorobenzylamine is an organic compound with the molecular formula C7H5F3N. It is characterized by the presence of three fluorine atoms attached to a benzene ring, with an amine group (-NH2) attached to the benzyl moiety. 2,4,6-TRIFLUOROBENZYL AMINE exhibits unique chemical properties due to the presence of fluorine atoms, which can influence its reactivity and stability in various applications.
Uses
Used in Chemical Synthesis:
2,4,6-Trifluorobenzylamine is used as an organic synthesis intermediate for the production of various chemical compounds. Its unique structure allows it to be a versatile building block in the synthesis of a wide range of molecules, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
2,4,6-Trifluorobenzylamine is used as a pharmaceutical intermediate, playing a crucial role in the development of new drugs. Its unique properties make it a valuable component in the design and synthesis of novel therapeutic agents, particularly those targeting specific biological pathways or receptors.
Used in Dye Production:
2,4,6-Trifluorobenzylamine is utilized in the preparation of dyes, particularly those with specific color properties or stability requirements. The presence of fluorine atoms in the molecule can enhance the color intensity and stability of the resulting dyes, making them suitable for various applications, such as textiles, plastics, and printing inks.
Used in Natural Gas and Refinery Process Streams:
In the energy sector, 2,4,6-trifluorobenzylamine is used in natural gas and refinery process streams. Its unique chemical properties make it suitable for various applications, such as catalysts, additives, or intermediates in the production and processing of hydrocarbons.
Used in Polymer Industry:
2,4,6-Trifluorobenzylamine is also used in the polymer industry as a monomer for the synthesis of polymers with specific properties. The incorporation of fluorine atoms in the polymer backbone can result in materials with enhanced thermal stability, chemical resistance, and other desirable characteristics.
Used as Additives in Lubricating Oils, Engine Fuels, and Asphalt:
2,4,6-Trifluorobenzylamine finds use as an additive in the production of lubricating oils, engine fuels, and asphalt. Its unique properties can improve the performance and stability of these materials, leading to enhanced product quality and performance.
Used in the Production of Ethanolamines:
2,4,6-Trifluorobenzylamine is also utilized in the production of ethanolamines, which are important intermediates in the chemical industry. These compounds are used in the manufacture of various products, including surfactants, detergents, and emulsifiers.
Synthesis
Put into 50 gram 2 into 1000ml autoclave, 4,6- trifluorobenzonitriles, 2.5 grams of raney-ni, 75 gram 25% of ammonia, 500 grams of methanol, control temperature to be 90 DEG C, and mixing speed is 350r/min, are passed through hydrogen hydrogenation, hydrogenation pressure 1mpa, logical hydrogen time 8 Hour reaction terminates, filtering catalyst raney-ni, the methanol in distillation gained filtrate, and distillation terminates addition dichloromethane extraction Take, extract elder generation normal pressure concentrated solvent, then vacuum distillation product, obtain 43.6 grams of product, 2,4,6- trifluoromethyl benzonitrile amine contents 99%, yield is calculated as 85% with 2,4,6- trifluorobenzonitriles.
Check Digit Verification of cas no
The CAS Registry Mumber 214759-21-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,7,5 and 9 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 214759-21:
(8*2)+(7*1)+(6*4)+(5*7)+(4*5)+(3*9)+(2*2)+(1*1)=134
134 % 10 = 4
So 214759-21-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H6F3N/c8-4-1-6(9)5(3-11)7(10)2-4/h1-2H,3,11H2
214759-21-4Relevant articles and documents
Preparation method of compound 2,4,6-trifluorobenzylamine
-
, (2021/03/11)
The invention discloses a preparation method of a compound 2,4,6-trifluorobenzylamine, and relates to the field of organic synthesis. According to the preparation method, pentachlorobenzonitrile is used as a starting raw material and is subjected to a fluorination reaction with a fluorinating agent in an organic solvent under the action of a catalyst to obtain 3,5-dichloro-2,4,6-trifluorobenzonitrile. The obtained 3,5-dichloro-2,4,6-trifluorobenzonitrile is added into water and reacts with zinc powder and mixed acid, and then reflux dechlorination is performed to obtain 2,4,6-trifluorobenzonitrile. The obtained 2,4,6-trifluorobenzonitrile is added into an organic solvent, and hydrogenation reduction is carried out under the action of an organic alkali and a catalyst to obtain the product 2,4,6-trifluorobenzylamine. The method has the advantages of short synthesis route, simple operation, mild reaction conditions, cheap and easily available raw materials and stable product quality, andis suitable for large-scale industrial production.
SYNTHESIS METHOD OF 2,4,6-TRIFLUOROBENZYLAMINE
-
Paragraph 0058-0064; 0066; 0068; 0070; 0072; 0076-0079, (2020/07/16)
The disclosure provides a synthesis method of 2,4,6-trifluorobenzylamine, belonging to the technical field of chemical synthesis. The synthesis method is characterized by comprising the following steps: (1) allowing pentachlorobenzonitrile as a raw material to undergo fluoridation reaction with a fluoridation agent based on 2,4,6-trifluoro-3,5-dichlorobenzonitrile as a solvent to obtain 2,4,6-trifluoro-3,5-dichlorobenzonitrile; (2) hydrogenating the obtained 2,4,6-trifluoro-3,5-dichlorobenzonitrile with hydrogen in the presence of organic carboxylic acid, based, on palladium carbon as a catalyst to obtain 2,4,6-trifluoro-3,5-dichlorobenzylamine; and (3) hydrogenating the obtained 2,4,6-trifluoro-3,5-dichlorobenzylamine with hydrogen in a solvent in the presence of a catalyst to obtain 2,4,6-trifluorobenzylamine. The synthesis method has the advantages of low raw material cost, short reaction steps, high reaction yield, good product purity simple operation and the like, and is suitable for industrial production.
Synthesis method of 2,4,6-trifluorobenzylamine
-
Paragraph 0005; 0008, (2018/10/27)
The invention relates to a synthesis method of 2,4,6-trifluorobenzylamine and mainly aims to solve the technical problem of lack of effective synthesis methods. The synthesis method comprises the following steps: continuously filling hydrogen chloride gas into a mixed solution with 1,3,5-trifluorobenzene, paraformaldehyde, ,sulfuric acid and acetic acid mixed solution of zinc chloride to generatea compound I; performing reaction on the compound I with urotropine to generate a quaternary ammonium salt compound II; and hydrolyzing the compound II in methyl alcohol and concentrated hydrochloricacid to generate a target compound III. The synthesis method is simple and few in steps, simple to operate, low in production cost, high in product purity and high in yield, and is suitable for industrial production.
