cas 215309-01-6, 3-(4-Methylpiperazin-1-yl)benzoic acid | Articles data ｜lookchem

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215309-01-6

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PURINES AS CYSTEINE PROTEASE INHIBITORS
Substituted heteroaryl nitrile derivatives of Formula I, processes for their preparation, pharmaceutical compositions comprising such compounds and use of the compounds as cysteine protease inhibitors are provided.
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Page/Page column 53

(2008/12/07)

Synthesis and serotonergic activity of variously substituted (3-amido)phenylpiperazine derivatives and benzothiophene-4-piperazine derivatives: Novel antagonists for the vascular 5-HT1B receptor
The synthesis and vascular 5-HT1B receptor activity of a novel series of substituted 3-amido phenylpiperazine and 4-(4-methyl-1-piperazinyl)-1- benzo[b]thiophene derivatives is described. Modifications to the amido linked sidechains of the 3-am
Moloney, Gerard P.,Garavelas, Agatha,Martin, Graeme R.,Maxwell, Miles,Glen, Robert C.
p. 305 - 321
(2007/10/03)

Protease inhibitors
The present invention provides bis-aminomethyl carbonyl protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.
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(2008/06/13)

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Chemical Properties

Melting Point: 187-190 °C
Boiling Point: 400.2 °C at 760 mmHg
Flash Point:195.8 °C
Density: 1.188 g/cm³
Storage Temp.:Sealed in dry,Room Temperature
Vapor Pressure: 4.02E-07mmHg at 25°C
Refractive Index: 1.579
PSA: 43.78000
LogP: 1.13950

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