- First Observation of a Thermal Contraction-Type Phase Transition in A-T-Isobars of Monolayers at the Air/Water Interface with Temperature Increase
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A-T-isobars of octadecylurea monolayers were measured.This is the first direct observation that the monolayers exhibited a first-order phase transition accompanying discontinuous molecular area contraction with increasing temperature.This may be due to the "fusion" of a hydrogen bonded bulky structure of urea head groups in the monolayers at the water surface.
- Kato, Teiji,Akiyama, Hideyuki,Yoshida, Masaaki
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- Hierarchical Self-Assembly of Amphiphilic β-C-Glycosylbarbiturates into Multiresponsive Alginate-Like Supramolecular Hydrogel Fibers and Vesicle Hydrogel
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Ordered molecular self-assembly of glycoamphiphiles has been regarded as an attractive, practical and bottom-up approach to obtain stable, structurally well-defined, and functional mimics of natural polysaccharides. This study describes a versatile and rational design of carbohydrate-based hydrogelators through N,N’-substituted barbituric acid-mediated Knoevenagel condensation onto unprotected carbohydrates in water. Amphiphilic N-substituted β-C-maltosylbarbiturates self-assembled into pH- and calcium-triggered alginate-like supramolecular hydrogel fibers with a multistimuli responsiveness to temperature, pH and competitive metal chelating agent. In addition, amphiphilic N,N’-disubstituted β-C-maltosylbarbiturates formed vesicle gels in pure water that were scarcely observed for glyco-hydrogelators. Finally, barbituric acid worked as a multitasking group allowing chemoselective ligation onto reducing-end carbohydrates, structural diversity, stimuli-sensitiveness, and supramolecular interactions by hydrogen bonding.
- Yao, Shun,Brahmi, Robin,Portier, Fran?ois,Putaux, Jean-Luc,Chen, Jing,Halila, Sami
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supporting information
p. 16716 - 16721
(2021/10/19)
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- N-[(2,6-disubstituted)phenyl]-urea and carbamate inhibitors of acyl-CoA:cholesterol acyl-transferase
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Substituted urea, thiourea, carbamate, and thiocarbamate derivatives of formula I are potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol.
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