Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides
The discovery of a novel class of HCV NS5B polymerase inhibitors, 3-arylsulfonylamino-5-phenyl-thiophene-2-carboxylic acids is described. SAR studies have yielded several potent inhibitors of HCV polymerase as well as of HCV subgenomic RNA replication in
Chan, Laval,Das, Sanjoy K.,Reddy, T. Jagadeeswar,Poisson, Carl,Proulx, Melanie,Pereira, Oswy,Courchesne, Marc,Roy, Caroline,Wang, Wuyi,Siddiqui, Arshad,Yannopoulos, Constantin G.,Nguyen-Ba, Nghe,Labrecque, Denis,Bethell, Richard,Hamel, Martine,Courtemanche-Asselin, Philippe,L'Heureux, Lucille,David, Maud,Nicolas, Olivier,Brunette, Stephanie,Bilimoria, Darius,Bedard, Jean
DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS
Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols according to formula (I) are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme.
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Paragraph 0298; 0299
(2014/01/07)
DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS
The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1 -phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
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Page/Page column 70
(2014/01/08)
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