- Method for synthesizing 1,3-dinitrohalobenzene compound
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The invention provides a method for synthesizing a 1,3-dinitrohalobenzene compound. The method comprises the following steps that A) a halogenated benzene compoundand mixed acid of nitric acid and sulfuric acid are subjected to a first nitrification reaction in a first-stage continuous flow microreactor, and oil-water separation is conducted to obtain a mononitrohalobenzene compound and first waste acid; B) the mononitrohalobenzene compound is drained into a second-stage continuous flow microreactor, a second nitrification reaction is conducted with the mixed acid of the nitric acid and the sulfuric acid, a generated nitration mixture is quenched at the outlet of the second-stage continuous flow microreactor, and filtering is conducted to obtain the 1,3-dinitrohalobenzene compound and second waste acid; C) the second waste acid is recycled to the first-stage continuous flow microreactor, a third nitration reaction with the halobenzene compound is carried out, the oil-water separation is conducted to obtain the mononitrohalobenzene compound and third waste acid, and steps B) and C) are repeated; the halobenzene compound has a structure shown in the formula I. The reaction time is short, the waste acid is less, and continuous production is achieved.
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Paragraph 0096; 0099; 0103; 0112; 0115-0120; 0121; 0124
(2019/07/16)
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- Preparation method of 4-(tert-butyl)-1-phenyl-imidazo[4,5,1-kl] phenoxazine
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The invention discloses a preparation method of 4-(tert-butyl)-1-phenyl-imidazo[4,5,1-kl] phenoxazine. The compound has a structure shown in formula I. The preparation method comprises the following steps of adopting p-tert-butyl phenol as a raw material, and obtaining p-tert-butyl ortho-dinitrochlorobenzene by nitrification of concentrated nitric acid; then adding DMF (Dimethyl Formamide) and sulfoxide chloride into a methylbenzene solvent system to carry out chlorination process; then carrying out Ullmann coupling reaction and ortho-aminophenol reaction to obtain 2-((4-(tert-butyl)-2,6-dinitrophenyl) amino)phenol); then adopting potassium hydroxide as an alkali, carrying out refluxing and ring closure under the environment of ethanol to obtain a phenoxazine mechanism; finally, reducing nitryl, and fusing rings with benzaldehyde to obtain a target compound, namely the 4-(tert-butyl)-1-phenyl-imidazo[4,5,1-kl] phenoxazine. The preparation method disclosed by the invention has the effects that due to a series of organic compounds, the range of organic photoelectric materials and pharmaceutical chemistry is expanded. (The formula I is described in the specification).
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Paragraph 0038; 0047; 0048
(2018/04/28)
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- CYTOKINE INHIBITORS
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The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines, such as for example arthritis, pain, cardiovascular disease and cancer.
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Page/Page column 123
(2008/12/07)
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- Halogenating agent and process for halogenating hydroxyl group
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A halogenating agent of the formula (1) and a method of halogenating hydroxyl group wherein R1 and R2 are the same or different and are each ethyl, propyl, isopropyl, butyl, isobutyl or allyl; X is chlorine atom or bromine atom; and Y is chlorine ion, bromine ion, dichlorophosphate ion, dibromophosphate ion, chlorosulfonate ion, bromosulfonate ion, chlorooxalate ion or bromooxalate ion.
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- Method for inhibiting the growth of tobacco suckers
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The growth of tobacco suckers in tobacco plants is inhibited by applying to the tobacco plants an effective amount of a substituted 2,6-dinitroaniline alone or in combination with a surfactant.
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- 4-Tert-butyl-N-sec-butyl-2,6-dinitroaniline
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The novel 4-tert-butyl-N-sec-butyl-2,6-dinitroaniline and its optically active enantiomorphs are useful as herbicides, piscicides, for aquatic weed control and for dodder control.
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