- Chiral-at-Rhodium Catalyst Containing Two Different Cyclometalating Ligands
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A method for the synthesis of a bis-cyclometalated rhodium complex containing two different cyclometalating ligands is reported and applied to asymmetric catalysis. The preparation of this previously inaccessible class of tris-heteroleptic bis-cyclometala
- Grell, Yvonne,Hong, Yubiao,Huang, Xiaoqiang,Mochizuki, Takuya,Xie, Xiulan,Harms, Klaus,Meggers, Eric
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- Method for synthesizing 1,3-dinitrohalobenzene compound
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The invention provides a method for synthesizing a 1,3-dinitrohalobenzene compound. The method comprises the following steps that A) a halogenated benzene compoundand mixed acid of nitric acid and sulfuric acid are subjected to a first nitrification reaction in a first-stage continuous flow microreactor, and oil-water separation is conducted to obtain a mononitrohalobenzene compound and first waste acid; B) the mononitrohalobenzene compound is drained into a second-stage continuous flow microreactor, a second nitrification reaction is conducted with the mixed acid of the nitric acid and the sulfuric acid, a generated nitration mixture is quenched at the outlet of the second-stage continuous flow microreactor, and filtering is conducted to obtain the 1,3-dinitrohalobenzene compound and second waste acid; C) the second waste acid is recycled to the first-stage continuous flow microreactor, a third nitration reaction with the halobenzene compound is carried out, the oil-water separation is conducted to obtain the mononitrohalobenzene compound and third waste acid, and steps B) and C) are repeated; the halobenzene compound has a structure shown in the formula I. The reaction time is short, the waste acid is less, and continuous production is achieved.
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Paragraph 0096-0098; 0112-0114; 0121-0123; 0130-0132; 0139
(2019/07/16)
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- Chiral Bis(oxazoline) Ligands as C2-Symmetric Chiral Auxiliaries for the Synthesis of Enantiomerically Pure Bis-Cyclometalated Rhodium(III) Complexes
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The synthesis of enantiomerically pure bis-cyclometalated rhodium(III) complexes using chiral bis(oxazoline) ligands as C2-symmetric chiral auxiliaries is described. Bis(oxazolines) are versatile chiral ligands for asymmetric catalysis but have
- Grell, Yvonne,Demirel, Nemrud,Harms, Klaus,Meggers, Eric
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supporting information
p. 3852 - 3859
(2019/11/13)
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- A synthesis method of uncle-butyl phenol
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The invention relates to a method for synthesizing 3-(tert-butyl)phenol. The method includes the following steps that 4-tert-butyl-1-chlorobenzene serves as a raw material and is nitrated to obtain 1-chlorine-4-tert-butyl-2-nitrobenzene; the 1-chlorine-4-tert-butyl-2-nitrobenzene is reduced to generate 3-tert-butylaniline; the 3-tert-butylaniline is diazotized and subjected to a hydrolysis reaction, and the 3-(tert-butyl)phenol is obtained. According to the path, the raw material is cheap and easy to get, elementary reaction conditions of the steps are mild, after-treatment is simple, the four-step reaction total yield is high, the 3-(tert-butyl)phenol with the purity higher than 97% can be obtained through distilling, and industrial production prospects are achieved.
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Paragraph 0021; 0022
(2017/09/12)
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- Method of producing aromatic amine compound having alkylthio group
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A method of producing an aromatic amine compound, that includes reducing an aromatic nitro compound that has an aromatic ring having an alkylthio group as a substituent, to obtain a corresponding aromatic amine compound, wherein the aromatic nitro compoun
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Page/Page column 13-14
(2008/06/13)
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