- Application of novel copper organic material for facile microextraction of sodium valproate from human plasma samples: Experimental design optimization and isotherm study
-
Well-designed metal organic materials (MOMs) were synthesized and applied for pre-concentration and determination of sodium valproate (Na-VP) from biological samples, bound to the copper complex of 1,4-phenylenedioxydiacetic acid under mild conditions. The channels of this sorbent provide high efficiency and also selectivity. The MOMs were structurally characterized using Fourier transform infrared and energy-dispersive X-ray spectroscopies, scanning electron microscopy and X-ray diffraction, and they were found to have suitable features for quantification of Na-VP using HPLC coupled with UV detection at λ?=?215?nm. Moreover, the rate of adsorption is improved by ultrasonic power and the experimental data are best fitted according to Freundlich adsorption isotherm. According to the central composite design, the best experimental conditions are 280.0?μl, 3.0?min and 17.0?mg for volume of eluent, sonication time and sorbent mass respectively. Calibration plots show linear responses towards Na-VP concentrations (0.4–18.0?μg ml?1), satisfactory limit of detection (0.06?μg ml?1, S/N?=?3) and reasonable enrichment factor (70.58). The coefficient of variation values of both inter- and intra-day analyses were less than 4.0%, indicating a candidate method for the determination of Na-VP in human plasma with reasonable recovery and efficiency.
- Bahrani, Sonia,Ghaedi, Mehrorang,Taghipour, Tahere,Mansoorkhani, Mohammad Javad Khoshnood,Bagheri, Ahmad Reza,Ostovan, Abbas
-
-
Read Online
- Turning the heat on conjugated polyelectrolytes: An off-on ratiometric nanothermometer
-
We report a self-referenced ratiometric nanothermometer based on short conjugated polyelectrolytes. An amphiphilic macromolecule destabilizes the polymer π-π stacking and makes it possible to shift the equilibrium between the less emissive aggregated state (520 nm) and the brighter individual chain (450 nm) within 20.0°C and 70.0°C.
- Darwish, Ghinwa H.,Koubeissi, Ali,Shoker, Tharallah,Abou Shaheen, Samir,Karam, Pierre
-
-
Read Online
- Photoelectro-Fenton/photocatalytic process for decolorization of an organic compound by Ag:Cd-1,4-BDOAH2 nano-photocatalyst: Response surface modeling and central composite design optimization
-
In the present research, the synthesis of the cadmium-benzene-1,4-dioxyacetic acid (Cd-1,4-BDOAH2) was carried out by the assistance of ultrasound waves, and then it was loaded with the low amount of Ag nano-particles. Subsequently, the Ag:Cd-1,4-BDOAH2 nano-photocatalyst was applied for photoelectro-Fenton/photocatalytic (PEF-PH) degradation of brilliant green (BG) in the existence of visible light in aqueous media. The synthesized composite was characterized by FTIR, SEM, EDX, TEM, XRD, DRS, and PL. The best operational conditions including time, initial BG concentration, pH, amount of photocatalyst, current and amount of FeCl3 on degradation efficiency (main and interactive) were as follows: 4 mg L?1 of BG at pH of 5, 0.4 g L?1 of Ag:Cd-1,4-BDOAH2, 250 mA of current, and 0.3 mmol L?1 of FeCl3 obtained by central composite design. The PEF-PH degradation kinetic data of BG were successfully fitted to Langmuir–Hinshelwood (L–H) model with the values of 1.16 mg L?1 min?1 and 0.018 L mg?1 for the rate constant (kr) and (KA), respectively.
- Taghipour, Tahere,Karimipour, Gholamreza,Ghaedi, Mehrorang,Asfaram, Arash,Javadian, Hamedreza,Sabzehmeidani, Mohammad Mehdi,Karimi, Hajir
-
-
- A color-tunable fluorescent pillararene coordination polymer for efficient pollutant detection
-
A dicarboxylatopillar[5]arene (DCP5)-based coordination polymer, namely DCP5-EuxTby, with color-tunable emission and capable of nitroaromatic pollutant detection, has been designed and fabricated via a typical metal-ligand coordination approach. Due to its rigid skeleton and electron-rich cavity, DCP5 plays an important role in this multi-color framework, not only as a linker but also as a blue-color fluorescence donor. Intriguingly, the fluorescent color of DCP5-EuxTby can be tuned from green to red simply by mediating the molar ratio of Eu3+ : Tb3+ in the functional system. More importantly, a white-color emitting system, that is, DCP5-Eu1Tb3, is discovered when the ratio of Eu3+ : Tb3+ is 1 : 3, and the white-light emissive DCP5-Eu1Tb3 exhibits good detection performance toward nitroaromatic pollutants in a wide application field. We envision that this work will open a new avenue for the exploration of synthetic macrocycle-based new materials in the construction of new fluorescent sensors and detectors for environmental sustainability and bio-related fields.
- Li, Xiang-Shuai,Li, Yong-Fu,Wu, Jia-Rui,Lou, Xin-Yue,Han, Junyou,Qin, Jianchun,Yang, Ying-Wei
-
supporting information
p. 3651 - 3657
(2020/02/26)
-
- Organic precipitator as well as preparation method and application thereof
-
The invention belongs to the field of rare earth gathering, and particularly relates to an organic precipitator as well as a preparation method and application thereof. The organic precipitator provided by the invention is prepared from one or more of structural compounds of formula (I) to formula (III), wherein R1, R2, R3 and R'3 are independently selected from hydrogen, substituted or non-substituted linear chain alkyl with the number of carbon atoms of 1 to 10, substituted or non-substituted branched alkyl with the number of the carbon atoms of 3 to 10, and substituted or non-substituted aryl; n is a natural integer; and M indicates cations. The organic precipitator provided by the invention has good selectivity to the rare earth and is very suitable for gathering rare-earth elements in a low-concentration rare-earth solution. The experiment result shows that when the organic precipitator provided by the invention is used for gathering the rare earth in the low-concentration rare earth solution, the precipitation speed is high, the purity of the gathered rare earth product is greater than 96 percent, and the yield is greater than 95 percent. (The formula (I) to (III) are shown in the description).
- -
-
Paragraph 0081-0083
(2018/09/08)
-
- Microwave (MW), ultrasound (US) and combined synergic MW-US strategies for rapid functionalization of pharmaceutical use phenols
-
Increasingly stringent regulations aimed at protection of the natural environment have stimulated the search for new synthetic methodologies in organic and medicinal chemistry having no or minimum harmful effect. An interesting approach is the use of alternative activation factors, microwaves (MW) or ultrasounds (US) and also their cross-combination, which has been tested in the fast and efficient creation of new structures. At present, an easy and green hybrid strategy (“Lego” chemistry) is generally recommended for the design of new substances from different chemistry building blocks. Often, selected biologically active components with specific chemical reactivities are integrated by a suitably designed homo- or heterodifunctional linker that modifies the functionality of the starting structure, allowing easy covalent linkage to another molecule. In this study, a fast introduction of heterodifunctional halogenoacidic linker to selected mono-, di- and triphenolic active substances, allowing their functionalization, was investigated. Nucleophilic substitution reaction was chosen to produce final ethers with the reactive carboxylic group from phenols. The functionalization was performed using various green factors initiating and supporting the chemical reactions (MW, US, MW-US). The benefits of the three green supporting methods and different conditions of reactions were analyzed and compared with the results of the reaction performed by conventional methods.
- Pawe?czyk, Anna,Sowa-Kasprzak, Katarzyna,Olender, Dorota,Zaprutko, Lucjusz
-
-
- Pillararene-Based Two-Component Thixotropic Supramolecular Organogels: Complementarity and Multivalency as Prominent Motifs
-
Rationally designed two-component supramolecular organogels based on multiple chemical interactions between percarboxylato- and peramino-pillararenes are described. Mixing low concentration solutions (gel values in some cases exceeding the boiling point of the embedded solvent. It is demonstrated that both structural complementarity and multivalency are important determinants in the gelation process of these attractive soft materials.
- Zafrani, Yossi,Kaizerman, Dana,Hadar, Maya,Bigan, Nitzan,Granot, Eran,Ghosh, Moumita,Adler-Abramovich, Lihi,Patolsky, Fernando,Cohen, Yoram
-
supporting information
p. 15750 - 15755
(2018/08/06)
-
- Reactions of peroxide products of ozonolysis of allyl ethers/esters in the AcOH-CH2Cl2 system on treatment with semicarbazide hydrochloride
-
Background: A one-pot method for the preparation of the corresponding alkoxy acetic acids by low-temperature ozonolysis of allyl ethers/esters followed by treatment with semicarbazide hydrochloride has been suggested. The reaction occurs via formation of acetoxyhydroperoxide, subsequent reduction of which depends on the process temperature and the nature of the starting substrate. Objective: The article is aimed at the development of one-pot method for obtaining practically important alkoxy acetic acids, because the ozonolytic cleavage of a ?=? double bond is the key step in full syntheses of many biologically active compounds. Methods: We used a low temperature ozonolysis of functionally substituted olefins in the system acetic acid-methylene dichloride followed by reduction of semicarbazide hydrochloride. To create a method we have used available allyl ethers/esters as starting materials. Results: We investigated reaction of the peroxide products of ozonolysis of monoallyl ethers, ester and diallyl ethers in an AcOH/CH2Cl2 mixture on treatment with semicarbazide hydrochloride at various temperatures. We have discovered that the selectivity of reduction of acetoxyhydroperoxide formed at the first stage depends both on the process temperature and on the nature of the starting substrate. A decrease in temperature favors acid hydrolysis and formation of a carboxylic acid. Conclusion: We have proposed a simple and highly efficient one-pot method for the preparation alkoxy acetic acids without isolation of intermediate peroxides.
- Raskil'dina, Gulnara Z.,Legostaeva, Yuliya V.,Garifullina, Liliya R.,Sultanova, Rimma M.,Ishmuratov, Gumer Y.,Zlotskii, Simon S.
-
p. 652 - 656
(2017/01/13)
-
- Synthesis, Structure, and Properties of the 2-[5-(Aryloxyacetyl)-Amino-1,3,4-Thiadiazol-2-Ylthio] Propionate Derivatives
-
A series of novel 2-[5-(aryloxyacetyl)-amino-1,3,4-thiadiazol-2-ylthio] propionate derivatives were synthesized in high yield, and their structures were characterized by IR, 1H NMR, 13C NMR, and elemental analysis, coupled with one selected single-crystal X-ray structure determination. The herbicidal activities of target compounds were assessed. The preliminary bioassay results showed that some compounds exhibited moderate to strong herbicidal symptoms in preemergence and postemergence tests. At 150 g/ha, S. tritici. show tolerance, while E. crus-galli L., E. Dahuricus, A. retroflexus, and C. glaucum L. were killed or severely injured. The activity of some compounds was comparable to the commercial herbicide 2,4-D. A suitable electron-withdrawing substituent at the 2-and/or 4-position of the phenyl ring was essential for high herbicidal activity. Moreover, the antifungal activities of the compounds have also been studied. The compounds were found to possess broad-spectrum antifungal activity.
- Hu, Bing,Zhai, Yue-Yuan,Zhang, Ling,Zhang, You-Ming,Wei, Tai-Bao
-
p. 1337 - 1345
(2015/10/29)
-
- Two 3D CdII and ZnII Complexes Based on Flexible Dicarboxylate Ligand and Nitrogen-containing Pillar: Synthesis, Structure, and Luminescent Properties
-
Two 3D isomorphous and isostructural complexes, namely, [Zn(BDOA)(bpy)(H2O)2]n (1) and [Cd(BDOA)-(bpy)(H2O)2]n (2); (BDOA = Benzene-1,4-dioxyacetic acid, bpy = 4,4'-bipyridine) were synthesized under hydrothermal conditions and characterized by means of elemental analyses, thermogravimetric (TG), infrared spectrometry, and single crystal X-ray diffraction. Complexes 1 and 2 crystallize in the triclinic system, space group P-1 and each metal ion in the complexes are six-coordinated with the same coordination environment. In the as-synthesized complexes, BDOA2- anions link central metal ions to form a 1D zigzag chain [-BDOA2-Zn(Cd)-BDOA2-Zn(Cd)-]∞, whereas bpy pillars connect metal ions to generate a 1D linear chain [-bpy-Zn(Cd)-bpy-Zn(Cd)-] ∞. Both infinite chains are interweaved into 2D grid-like layers which are further constructed into a 3D open framework, where hydrogen bonds play as the bridges between the adjacent 2D layers. Luminescent properties of complex 1 showed selectivity for Hg2+ ion.
- Liu, Liu,Fan, Yan-Hua,Wu, Lan-Zhi,Zhang, Huai-Min,Yang, Li-Rong
-
p. 3749 - 3754
(2014/01/17)
-
- Functionalized biodegradable triclosan monomers and oligomers for controlled release
-
This invention relates to the discovery of functionalized triclosan monomers and oligomers that, when incorporated into a substrate of, or applied as part of a coating to, medical devices and/or consumer products may extend the duration of antimicrobial properties to the medical devices and/or consumer products.
- -
-
-
- Synthesis of novel amides of phenyl-1, 4-dioxyacetic acid as molecular tweezers and studies on their molecular recognition
-
A simple efficient method for the synthesis of novel amides of phenyl-1, 4-dioxyacetic acid as molecular tweezers under solvent-free conditions and microwave irradiation has been developed. Its main advantages are short reaction times, good conversions and the environmentally friendly nature of the process. The structures of the products were confirmed by IR, 1H NMR, MS spectra and elemental analyses and their binding properties were examined by UV-vis spectral titration. Preliminary results indicated that these molecular tweezers show good selectivity for neutral organic molecules.
- Li, Wei Jie,Zhao, Zhi Gang,Liu, Xingli,Wang, Xiao Qing
-
experimental part
p. 399 - 402
(2010/11/18)
-
- Microwave-assisted synthesis of novel aryloxyacetyl hydrazones molecular tweezers under solvent-free conditions
-
A rapid, efficient and eco-friendly method for the preparation of new aryl-1,4-bisoxyacetylhydrazone molecular tweezers was reported. The reaction is accelerated by microwave irradiation under solvent-free conditions in the presence of solid Al2O3. The structures of these new molecular tweezers were characterised by 1H NMR, IR, MS spectra and elemental analysis.
- Zhao, Zhi-Gang,Liu, Xing-Li,Shi, Zhi-Chuan,Chen, Yu
-
experimental part
p. 208 - 210
(2010/08/06)
-
- CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS
-
The present invention relates to biodegradable polymers (e.g., polyesters and polyester amides) derived from functionalized biologically active compounds that can provide site specific delivery of bioactive compounds upon biodegradation in a controlled manner.
- -
-
-
- FUNCTIONALIZED PHENOLIC COMPOUNDS AND POLYMERS THEREFROM
-
The present invention relates to compounds of formula I, which are functionalized phenolic compounds, and polymers formed from the same. Ar—[O—(X)p—R′]q??I Polymers formed from the functionalized phenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
- -
-
Page/Page column 35-36
(2009/07/17)
-
- FUNCTIONALIZED BIODEGRADABLE TRICLOSAN MONOMERS AND OLIGOMERS FOR CONTROLLED RELEASE
-
This invention relates to the discovery of functionalized triclosan monomers and oligomers that, when incorporated into a substrate of, or applied as part of a coating to, medical devices and/or consumer products may extend the duration of antimicrobial properties to the medical devices and/or consumer products.
- -
-
-
- Dihydroxy aromatic compounds and methods for preparation
-
A dihydroxy aromatic compound having a Formula (I), wherein R1 is a C6–C60 aromatic divalent functionality, R2 at each occurrence, can be the same or different and is independently at each occurrence selected from the group consisting of a cyano functionality, a nitro functionality, a halogen, an aliphatic functionality having 1 to 10 carbons, a cycloaliphatic functionality having 3 to 10 carbons and an aromatic functionality having 6 to 10 carbons, and “n” is an integer having a value of 0 to 4.
- -
-
Page/Page column 14-15
(2010/11/25)
-
- A rapid and high-yield synthesis of aryloxyacetic acid in one pot under microwave irradiation and phase transfer catalysis conditions
-
A series of aryloxyacetic acid 3a-h has been synthesized in one pot under microwave irradiation and phase transfer catalysis conditions. By the optimization of the reaction condition, a rapid, high-yield and efficient method for the preparation of aryloxyacetic acid is reported.
- Wei, Tai-Bao,Liu, Hong,Li, Man-Lin,Zhang, You-Ming
-
p. 1312 - 1314
(2007/10/03)
-
- Polymeric salen-Ti(IV) or V(V) complex catalyzed asymmetric synthesis of O-acetylcyanohydrins from KCN, Ac2O and aldehydes
-
Polymeric salen-Ti(IV) and V(V) complexes were employed in the enantioselective O-acetyl cyanation of aldehydes with potassium cyanide and acetic anhydride. The crosslinked polymeric salen-Ti(IV) catalyst exhibited good activities and enantioselectivities, up to 91% ee with 99% conversion was obtained at -20°C with 1 mol% of catalyst (based on bimetallic catalytic unit). Moreover, six consecutive recyclings with the easily recovered crosslinked polymeric catalyst showed no obvious decrease in either activity or enantioselectivity. Linear polymeric salen-V(V) catalyst showed good catalytic efficiency too, up to 94% ee with 99% conversion was obtained at -42°C with 5 mol% of catalyst. Graphical Abstract.
- Huang, Wei,Song, Yuming,Wang, Jing,Cao, Guoying,Zheng, Zhuo
-
p. 10469 - 10477
(2007/10/03)
-
- Highly enantioselective resolution of terminal epoxides with cross-linked polymeric salen-Co(III) complexes
-
Crosslinked polymeric salen-Co(III) complexes derived from a novel dialdehyde and a trialdehyde were synthesized and employed in the hydrolytic kinetic resolution (HKR) of terminal epoxides. Up to 99% ee were obtained with only 0.16-0.02 mol% of catalyst (based on catalytic unit).
- Song, Yuming,Chen, Huilin,Hu, Xinquan,Bai, Changmin,Zheng, Zhuo
-
p. 7081 - 7085
(2007/10/03)
-
- New bis-aminomercaptotriazoles and bis-triazolothiadiazoles as possible anticancer agents
-
A series of bis-phenoxyacetic acids 2 were prepared starting from corresponding unsubstituted/substituted 1,4-quinols 1. The fusion of bis-phenoxyacetic acids 2 with thiocarbohydrazide gave the corresponding bis-[4-amino-5-mercapto-1,2,4-triazol-3-yl-methyleneoxy]phenylenes (3) in a one pot reaction. The reaction of bis-triazoles 3 with various reagents afforded N-bridged heterocycles 4-6 in good yields. The newly synthesised compounds were screened for their anticancer activity against a panel of 60 cell lines derived from seven cancer types namely, lung, colon, melanoma, renal, ovarian, CNS and leukemia. Some of the tested compounds showed promising anticancer properties.
- Shivarama Holla,Narayana Poojary,Sooryanarayana Rao,Shivananda
-
p. 511 - 517
(2007/10/03)
-
- Synthesis of 1,1,1-trichloro-2,2-bis-(carboxymethoxyaryl)ethanes as potential antimicrobial and insecticidal agents
-
Some new 1,1,1-trichloro-2,2-bis-(carboxymethoxyaryl)-ethanes 2a-t have been synthesised by the treating aryloxyacetic acid (two moles) with chloral hydrate (1 mole) in the presence of catalytic amount of conc. sulphuric acid. The aryloxyacetic acid are prepared by the reaction of substituted phenols with chloroacetic acid in the presence of aq. sodium hydroxide. The antimicrobial activity of these compounds have been assayed against various Gram+ve, Gram-ve bacteria and fungi. The constitution of the products have been elucidated by IR, 1H NMR and mass spectral data and elemental analyses.
- Purohit,Shah
-
p. 618 - 622
(2007/10/03)
-
- Solvent-free synthesis of substituted phenoxyacetic acids under microwave irradiation
-
A comparison of microwave-activated vs. classical organic synthesis is presented for a variety of growth-regulator compounds with a phenoxyacetic acid structure. Microwave-assisted nucleophilic substitutions are safely and conveniently carried out in an open vessel, without any solvent. Yields are very good, and reaction times are extremely short.
- Nagy, Gabriela,Filip, Sorin V.,Surducan, Emanoil,Surducan, Vasile
-
p. 3729 - 3736
(2007/10/03)
-
- Cyclobis(paraquat-4,4'-biphenylene) - An Organic Molecular Square
-
Template-directed syntheses of cyclobis(paraquat-4,4'-biphenylene) (1) - a molecular square - have been achieved by use of ?-electron-rich macrocyclic hydroquinone-based and acyclic ferrocene-based templates.In particular, the use of a polyether-disubstituted ferrocene derivative as a template permits synthesis of 1 (which is accessible only in very low yields without templates) on a preparative scale.Furthermore, the use of a macrocyclic hydroquinone-based polyether template incorporating an ester function in one polyether chain - an "oriented" macrocycle - affords a 1:1 mixture of two topologically stereoisomers catenanes.Ester hydrolysis of the ?-electron-rich macrocyclic components mechanically interlocked with 1 within the catenated structures releases the tetracationic cyclophane in quantitative yield as a result of the degradation of the catenanes.The molecular square has been characterized by X-ray crystallography, FAB mass spectrometry, 1H NMR and 13C NMR spectroscopies, and elemental analysis.The binding properties of 1 and of the smaller cyclophane cyclobis(paraquat-p-phenylene) toward a series of ?-electron-rich guests have also been investigated with the above techniques and UV/VIS spectroscopy.The self-assembly of the resulting supramolecular complexes in solution and in the solid state is driven mainly by ?-? stacking interactions and hydrogen-bonding interactions, as well as by edge-to-face T-type interactions.In particular, the complexation of ferrocene or a ferrocene-based derivative within the cavity of 1 suggests the possibility of constructing functioning ferrocene-based molecular and supramolecular devices that can be controlled electrochemically in the form of catenanes, rotaxanes, and pseudorotaxanes. -Keywords: catenanes; second-sphere coordination; self-assembly; template syntheses; topological stereoisomerism
- Asakawa, Masumi,Ashton, Peter R.,Menzer, Stephan,Raymo, Francisco M.,Stoddart, J. Fraser,et al.
-
p. 877 - 893
(2007/10/03)
-
- Phase transfer catalyzed synthesis of diaryl 1,4-phenylene dioxydiacetate
-
The title compounds 3a-3o were prepared with high yield via the reaction of 1,4-phenylenedioxydiacetyl chloride with various substituted phenols under the condition of liquid-liquid phase transfer catalysis, using polyethylene glycol - 400 as the catalyst.
- Wei, Taibao,Chen, Jichou,Wang, Xicun,Zhang, Youming,Wang, Lailai
-
p. 1447 - 1454
(2007/10/03)
-
- THE FORMATION OF COMPLEXES BETWEEN AZA DERIVATIVES OF CROWN ETHERS AND PRIMARY ALKYLAMMONIUM SALTS. PART 9. BICYCLIC DERIVATIVES OF DIAZA CROWN ETHERS
-
The bridged diaza-15-crown-5 derivatives (12a-c) and (16) form complexes with alkylammonium cations RN(+)H3 in organic solvents.The 1H n.m.r.spectra of the complexes (12).RN(+)H3 show that they are mostly of the inclusion type (3) but in a few cases a second diastereoisomeric complex, possibly (4), is also formed.These bicyclic hosts do not show particularly high selectivity in complexation on the basis of competition between pairs of guest cations.
- Kyte, Andrew B.,Owens, Ken A.,Sutherland, Ian O.,Newton, Roger F.
-
p. 1921 - 1928
(2007/10/02)
-