- Nanometer medicine for photothermal-photodynamic combined treatment of tumors as well as preparation method and application of nanometer medicine
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The invention discloses a nanometer medicine for photothermal-photodynamic combined treatment of tumors as well as a preparation method and application of the nanometer medicine and belongs to the technical field of biomedicines. The nanometer medicine comprises pillararene P-2PEG and a photosensitizer DBDP, and the photosensitizer DBDP is wrapped in pillararene by the pillararene P-2PEG. A preparation process of the nanometer medicine is simple, and the prepared nanometer medicine is good in water solubility, high in photothermal conversion efficiency, capable of generating two high active oxygen species, high in photodynamic activity and capable of achieving efficient photothermal and photodynamic combined treatment on deep tumors.
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Paragraph 0027-0030
(2021/12/01)
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- A pillar[5]arene based gel from a low-molecular-weight gelator for sustained dye release in water
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A soft gel based on pillar[5]arene was successfully prepared using a carbazone reaction. Furthermore, dyes such as TPP or TPPE can be incorporated into this gel and were observed to be released in a sustained way in water due to solvent exchange.
- Yao, Yong,Sun, Yan,Yu, Huaxu,Chen, Wenrui,Dai, Hong,Shi, Yujun
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supporting information
p. 16802 - 16806
(2017/12/26)
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- Functionalized biodegradable triclosan monomers and oligomers for controlled release
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This invention relates to the discovery of functionalized triclosan monomers and oligomers that, when incorporated into a substrate of, or applied as part of a coating to, medical devices and/or consumer products may extend the duration of antimicrobial properties to the medical devices and/or consumer products.
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Page/Page column 57
(2011/11/13)
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- FUNCTIONALIZED PHENOLIC COMPOUNDS AND POLYMERS THEREFROM
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The present invention relates to compounds of formula I, which are functionalized phenolic compounds, and polymers formed from the same. Ar—[O—(X)p—R′]q??I Polymers formed from the functionalized phenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
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Page/Page column 31
(2009/07/17)
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- CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS
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The present invention relates to biodegradable polymers (e.g., polyesters and polyester amides) derived from functionalized biologically active compounds that can provide site specific delivery of bioactive compounds upon biodegradation in a controlled manner.
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- FUNCTIONALIZED BIODEGRADABLE TRICLOSAN MONOMERS AND OLIGOMERS FOR CONTROLLED RELEASE
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This invention relates to the discovery of functionalized triclosan monomers and oligomers that, when incorporated into a substrate of, or applied as part of a coating to, medical devices and/or consumer products may extend the duration of antimicrobial properties to the medical devices and/or consumer products.
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- A rapid and high-yield synthesis of aryloxyacetic acid in one pot under microwave irradiation and phase transfer catalysis conditions
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A series of aryloxyacetic acid 3a-h has been synthesized in one pot under microwave irradiation and phase transfer catalysis conditions. By the optimization of the reaction condition, a rapid, high-yield and efficient method for the preparation of aryloxyacetic acid is reported.
- Wei, Tai-Bao,Liu, Hong,Li, Man-Lin,Zhang, You-Ming
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p. 1312 - 1314
(2007/10/03)
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- Rapid and high-yield synthesis of aryloxyacetates under microwave irradiation and phase-transfer catalysis conditions
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A series of methyl aryloxyacetates (3a-3f) have been synthesized by the reaction of substituted phenol with methyl chloroacetate under the conditions of microwave irradiation and phase-transfer catalysis. By the optimization of the reaction conditions, we developed a good method for the preparation of methyl aryloxyacetates, which have the advantages of high yields, short reaction times, ease of workup, and simple operation. Copyright Taylor & Francis, Inc.
- Wei, Tai-Bao,Liu, Hong,Li, Man-Lin,Zhang, You-Ming
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p. 1759 - 1764
(2007/10/03)
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- A rapid and high-yield synthesis of aryloxyacetyl hydrazides under microwave irradiation and with phase transfer catalysis
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A series of aryloxyacetyl hydrazides 4a-l were synthesised under microwave irradiation and phase transfer catalysis conditions. By the optimisation of the reaction conditions, a rapid, high-yield and efficient method for the preparation of aryloxyacety hydrazide was given.
- Wei, Tai-Bao,Liu, Hong,Li, Man-Lin,Zhang, You-Ming
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p. 432 - 433
(2007/10/03)
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- The synthesis of macrocyclic diamides and tetramides containing phenol units
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Thirteen new macrocyclic diamides and tetramides have been synthesized by reaction of methyl phenoxyacetates (readily obtained from various phenols) with α,ω-diamines in methanol as a solvent. Relationship between structure of esters and ratio of diamides to tetraamides has been investigated.
- Gryko, Daniel T.,Piatek, Piotr,Jurczak, Janusz
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p. 7957 - 7966
(2007/10/03)
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- Cyclobis(paraquat-4,4'-biphenylene) - An Organic Molecular Square
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Template-directed syntheses of cyclobis(paraquat-4,4'-biphenylene) (1) - a molecular square - have been achieved by use of ?-electron-rich macrocyclic hydroquinone-based and acyclic ferrocene-based templates.In particular, the use of a polyether-disubstituted ferrocene derivative as a template permits synthesis of 1 (which is accessible only in very low yields without templates) on a preparative scale.Furthermore, the use of a macrocyclic hydroquinone-based polyether template incorporating an ester function in one polyether chain - an "oriented" macrocycle - affords a 1:1 mixture of two topologically stereoisomers catenanes.Ester hydrolysis of the ?-electron-rich macrocyclic components mechanically interlocked with 1 within the catenated structures releases the tetracationic cyclophane in quantitative yield as a result of the degradation of the catenanes.The molecular square has been characterized by X-ray crystallography, FAB mass spectrometry, 1H NMR and 13C NMR spectroscopies, and elemental analysis.The binding properties of 1 and of the smaller cyclophane cyclobis(paraquat-p-phenylene) toward a series of ?-electron-rich guests have also been investigated with the above techniques and UV/VIS spectroscopy.The self-assembly of the resulting supramolecular complexes in solution and in the solid state is driven mainly by ?-? stacking interactions and hydrogen-bonding interactions, as well as by edge-to-face T-type interactions.In particular, the complexation of ferrocene or a ferrocene-based derivative within the cavity of 1 suggests the possibility of constructing functioning ferrocene-based molecular and supramolecular devices that can be controlled electrochemically in the form of catenanes, rotaxanes, and pseudorotaxanes. -Keywords: catenanes; second-sphere coordination; self-assembly; template syntheses; topological stereoisomerism
- Asakawa, Masumi,Ashton, Peter R.,Menzer, Stephan,Raymo, Francisco M.,Stoddart, J. Fraser,et al.
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p. 877 - 893
(2007/10/03)
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