The combination of hydroformylation and biocatalysis for the large-scale synthesis of (S)-allysine ethylene acetal
The compound, (S)-2-amino-5-[1,3]dioxolan-2-yl-pentanoic acid [(S)-allysine ethylene acetal], is a key intermediate in a number of angiotension-I converting enzyme (ACE) and neutral endopeptidase (NEP) inhibitors currently in clinical trials. Through a co
Cobley, Christopher J.,Lloyd, Michael C.,Simmonds, Shaun,Hanson, Christopher H.,Peng, Wei Jun
experimental part
p. 284 - 290
(2011/10/02)
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