- A New Indirect Application of Aggregative Activation: Synthesis of Esters by Cobalt-Catalyzed Carbonylation of Aryl, Heterocyclic, and Vinyl Halides under Atmospheric Pressure
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Sun lamp illuminated alkoxycarbonylation of aryl, heteroaryl, and vinyl halides was performed under atmospheric pressure of CO in the presence of a cobalt catalyst in situ generated from Co(OAc)2.Illunination through a Pyrex flask was sufficient to catalyze the reaction.This process avoids the use of Co2(CO)8 and excess CH3I, which were required in the earlier procedure.A SRN1 mechanism is proposed.
- Marchal, Joel,Bodiguel, Jacques,Fort, Yves,Caubere, Paul
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p. 8336 - 8340
(2007/10/02)
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- An efficient cobalt catalyzed alkoxycarbonylation of aryl and heteroaryl halides
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Cobalt carbonyl catalyzed carbonylation (1 atm) of aryl and heteroaryl halides may be easily achieved with CoCRACO in alcohol under photostimulation to afford the corresponding esters in high yield. Irradiation may be achieved very easily with a commercial sun lamp. Easy to prepare and handle on a preparative scale, CoCRACO must be regarded as very promising tool in the preparation of various esters.
- Vanderesse,Marchal,Caubere
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p. 1361 - 1370
(2007/10/02)
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- SYNTHESIS OF 4-CARBOXY-2-THIABICYCLOHEPTAN-6-ONES VIA 3-CARBOXY-2,3-DIHYDROTHIOPHENES: POTENTIAL β-LACTAMASE INHIBITORS
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3-Carboalkoxy-2,3-dihydrothiophenes, available by Birch reduction of thiophene-3-carboxylic acid or more efficiently by deconjugation of 2,5-dihydrothiophene-3-carboxylic acid by reaction with ethyl chloroformate and triethylamine, undergo cycloaddition reactions with dichloroketene leading to 4-carboxy-7,7-dichloro-2-thiabicycloheptan-6-ones which are of interest as potential β-lactamase inhibitors.
- Lange, Gerald,Savard, Marc E.,Viswanatha, Thammaiah,Dmitrienko, Gary I.
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p. 1791 - 1794
(2007/10/02)
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