- Diels-Alder reactions for the rational design of benzo[b]thiophenes: DFT-based guidelines for synthetic chemists
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In this work we studied the capability of several diene/dienophile pairs to undergo Diels-Alder (DA) reactions leading to benzo[b]thiophenes. A variety of synthetically and commercially available nitrothiophenes were chosen as dienophiles. Methyl 5-nitro-3-thiophenecarboxylate was selected as a potential strong electrophilic candidate based on some DFT-based properties and the substitution pattern of the expected product. The mechanistic details concerning the participation of this dienophile in polar DA reactions were investigated through a theoretical point of view. The results were compared with the experimental outcomes. This methodology should allow synthetic chemists to analyze DA reactions in detail in a stage prior to the synthetic job.
- Brasca, Romina,Kneeteman, María N.,Mancini, Pedro M.E.,Fabian, Walter M.F.
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experimental part
p. 158 - 168
(2012/03/22)
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- IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS
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In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or Aurora kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or Aurora kinases using such compounds or pharmaceutical compositions.
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Page/Page column 130-131
(2009/01/23)
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- ANTIFUNGAL AGENTS
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Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents: (I) wherein: Rl, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (T), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.
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Page/Page column 44
(2008/06/13)
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- Synthesis of highly potent and selective hetaryl ureas as integrin αVβ3-receptor antagonists
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Solid-phase synthesis and SAR of integrin αVβ3-receptor antagonists containing a urea moiety as non-basic guanidine mimetic are described. The most potent compounds exhibited IC50 values towards αVβ3 in the nanomolar range and high selectivity versus related integrins like αIIbβ3. For selected examples efficacy in functional cellular assays is demonstrated.
- Lange, Udo E.W.,Backfisch, Gisela,Delzer, Juergen,Geneste, Herve,Graef, Claudia,Hornberger, Wilfried,Kling, Andreas,Lauterbach, Arnulf,Subkowski, Thomas,Zechel, Christian
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p. 1379 - 1382
(2007/10/03)
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- Meisenheimer-type Adducts from Thiophene Derivates. Part 6. A Kinetic and Thermodynamic Study of Substituent Effects on the Formation of Some non-gem Adducts
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The rate and equilibrium constants for the formation of the Meisenheimer-type adducts from some 4-nitro-2-X- (5) or some 2-nitro-4-X-thiophenes (7) and sodium methoxide have been measured at 25 deg C in methanol or methanol-dimethyl sulphoxide mixtures.The observed stability and reactivity patterns have been interpreted in the light of the hyper-ortho relation in the thiophene ring and the special ability of the nitro group to stabilize effectively the adducts from a para-like position also.
- Arnone, Caterina,Consiglio, Giovanni,Spinelli, Domenico,Dell'Erba, Carlo,Sancassan, Fernando,Terrier, Francois
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p. 1609 - 1612
(2007/10/02)
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