- Phenyl-imidazolo-cytidine analogues: Structure-photophysical activity relationship and ability to detect single dna mismatch
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To expand the arsenal of fluorescent cytidine analogues for the detection of genetic material, we synthesized para-substituted phenyl-imidazolo-cytidine (PhImC) analogues 5a-g and established a relationship between their structure and fluoresce
- Kovaliov, Marina,Weitman, Michal,Major, Dan Thomas,Fischer, Bilha
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p. 7051 - 7062
(2014/08/18)
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- Mapping the landscape of potentially primordial informational oligomers: Oligodipeptides tagged with 2,4-disubstituted 5-aminopyrimidines as recognition elements
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(Chemical Equation Presented) Bit different: 2,4-Dioxo- and 2,4-diamino-5-aminopyrimidine nuclei attached to an oligodipeptide backbone display a disparity in their base-pairing strength which is opposite to that shown by corresponding triazines. This behavior points to a remarkable correlation between pairing strength and ΔpKa values of pairs of complementary bases.
- Mittapalli, Gopi Kumar,Osornio, Yazmin M.,Guerrero, Miguel A.,Reddy, Kondreddi Ravinder,Krishnamurthy, Ramanarayanan,Eschenmoser, Albert
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p. 2478 - 2484
(2008/03/11)
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- 3-deoxyglucosone and skin
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The invention relates to a method of removing 3-deoxyglucosone and other alpha-dicarbonyl sugars from skin. The invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin. The invention also relates to methods of treating 3-deoxyglucosone and other alpha-dicarbonyl sugars associated diseases and disorders of skin.
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- Regioselective Addition of Grignard Reagents to a 2-Oxopurinium Salt
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Treatment of 6-ethoxy-1,3,6,7-tetrahydro-1,3,7-tribenzyl-2H-purin-2-one with trimethylchlorosilane gave a stable tribenzylated 2-oxopurinium salt, which selectively added Grignard reagents in the 6-position.The structure of the adducts were established fr
- Andresen, Geir,Gundersen, Lise-Lotte,Lundmark, Max,Rise, Frode,Sundell, Staffan
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p. 3655 - 3664
(2007/10/02)
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- Amino-substituted pyrimidines, derivatives and methods of use therefor
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The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation end products of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
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- Nucleoside process
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Process for producing 1-halo-2-deoxy-2-fluoroarabinofuranoside derivatives bearing protective ester groups from 1,3,5-tri-O-acylribofuranose; the 1-halo compounds are intermediates in the synthesis of therapeutically active nucleosidic compounds.
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