- Synthesis of isothiocyanates using DMT/NMM/TsO? as a new desulfurization reagent
-
Thirty-three alkyl and aryl isothiocyanates, as well as isothiocyanate derivatives from esters of coded amino acids and from esters of unnatural amino acids (6-aminocaproic, 4-(aminomethyl)benzoic, and tranexamic acids), were synthesized with satisfactory or very good yields (25–97%). Synthesis was performed in a “one-pot”, two-step procedure, in the presence of organic base (Et3 N, DBU or NMM), and carbon disulfide via dithiocarbamates, with 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium toluene-4-sulfonate (DMT/NMM/TsO? ) as a desulfurization reagent. For the synthesis of aliphatic and aromatic isothiocyanates, reactions were carried out in a microwave reactor, and selected alkyl isothiocyanates were also synthesized in aqueous medium with high yields (72–96%). Isothiocyanate derivatives of L-and D-amino acid methyl esters were synthesized, under conditions without microwave radiation assistance, with low racemization (er 99 > 1), and their absolute configuration was confirmed by circular dichroism. Isothiocyanate derivatives of natural and unnatural amino acids were evaluated for antibacterial activity on E. coli and S. aureus bacterial strains, where the most active was ITC 9e.
- Janczewski, ?ukasz,Kolesińska, Beata,Kr?giel, Dorota
-
-
- Synthesis and antitumor activity of novel pyridazinone derivatives containing 1,3,4-thiadiazole moiety
-
A series of novel pyridazinone derivatives containing the 1,3,4-thiadiazole moiety were synthesized and characterized by 1H NMR, 13C NMR, spectroscopies HRMS and IR. Among them, the structure of compound 5c (2-(Tert-butyl)?4-chloro-5-((5-((2-ethylphenyl)amino)?1,3,4-thiadiazol-2-yl)thio)pyridazin-3(2H)-One) was unambiguously confirmed via single crystal X-ray diffraction analysis. The inhibitory activity of all the target compounds against MGC-803 and Bcap-37 was determined by MTT assay, with doxorubicin (the inhibition rates were 95.5 ± 0.4% and 95.7 ± 1.0% respectively) as a control. The preliminary results showed that the inhibitory activity of compound 5n (2-(Tert-butyl)?4-chloro-5-((5-((3-fluorophenyl)amino)?1,3,4-thiadiazol-2-yl)thio)pyridazin-3(2H)-One) was superior to the others. The inhibition rates of MGC-803 and Bcap-37 cells were 86.3 ± 2.2% and 92.3 ± 0.6% at a concentration of 10 μmol/L, respectively. The preliminary structure-activity relationship showed that when the 2-position of the benzene ring was substituted by a methyl group, such as compound 5j (2-(Tert-butyl)?4-chloro-5-((5-((2,3-dimethylphenyl)amino)?1,3,4-thiadiazol-2-yl)thio)pyridazin-3(2H)-One), it exhibited good anticancer activity on MGC-803 cells. Besides, introducing fluorine, chlorine, or trifluoromethyl group onto the benzene ring, such as compound 5 m (2-(Tert-butyl)?4-chloro-5-((5-((4-(trifluoromethoxy)phenyl)amino)?1,3,4-thiadiazol-2-yl)thio)pyridazin-3(2H)-One), displayed good anticancer activity on MGC-803 and Bcap-37 cells.
- Qin, Junhu,Zhu, Mei,Zhu, Hongmei,Zhang, Liqiong,Fu, Yihong,Liu, Jiamin,Wang, Zhenchao,OuYang, Guiping
-
p. 592 - 599
(2020/03/16)
-
- Direct, Microwave-Assisted Synthesis of Isothiocyanates
-
A microwave-assisted desulfuration of readily available dithiocarbamates, formed in situ from primary amines, leading to target isothiocyanates has been developed. This efficient protocol provides a rapid, environmentally benign route to aliphatic and aromatic isothiocyanates.
- Janczewski, ?ukasz,Gajda, Anna,Gajda, Tadeusz
-
p. 2528 - 2532
(2019/04/03)
-
- Na2S2O8-mediated efficient synthesis of isothiocyanates from primary amines in water
-
We have developed two green, practical, and efficient procedures, including a one-pot one, to synthesize isothiocyanates from amines and carbon disulfide via desulfurization with sodium persulfate. Water is used as the solvent. Basic conditions are necessary for good chemoselectivity for isothiocyanates. Structurally diverse linear and branched alkyl amines and aryl amines are readily converted to isothiocyanates by the two procedures in satisfactory yields. Halogens, benzylic C-H bonds, methylthio, nitro, ester, alkenyl, electron-rich or -deficient (hetero)aryls, acetylenyl, and even phenolic and alcoholic hydroxyls are well tolerated. The one-pot procedure in water can also be used to realize the preparation of chiral isothiocyanates from chiral amines, and the modification of bioactive structures with free amino groups. In large-scale preparation, simple and practical purification procedures independent of column chromatography are developed.
- Fu, Zhicheng,Yuan, Wenhao,Chen, Ning,Yang, Zhanhui,Xu, Jiaxi
-
p. 4484 - 4491
(2018/10/17)
-
- T3P - A Benign Desulfurating Reagent in the Synthesis of Isothiocyanates
-
A number of alkyl, aryl and bifunctional isothiocyanates are obtained in moderate to high yields (41-94%) in a two-step, one-pot reaction of the parent primary amines or their salts with carbon disulfide, followed by reaction of the thus formed dithiocarbamates with T3P (propane phosphonic acid anhydride) as a new and efficient desulfurating agent.
- Janczewski, ?ukasz,Gajda, Anna,Frankowski, Sebastian,Goszczyński, Tomasz M.,Gajda, Tadeusz
-
p. 1141 - 1151
(2017/12/06)
-
- Reaction of Thiocarbonyl Fluoride Generated from Difluorocarbene with Amines
-
The reaction of thiocarbonyl fluoride, generated from difluorocarbene, with various amines under mild conditions is described. Secondary amines, primary amines, and o-phenylenediamines are converted to thiocarbamoyl fluorides, isothiocyanates, and difluoromethylthiolated heterocycles, respectively. Thiocarbamoyl fluorides were further transformed into trifluoromethylated amines by using a one-pot process. Thiocarbonyl fluoride is generated in situ and is rapidly fully converted in one pot under mild conditions; therefore, no special safety precautions are needed.
- Yu, Jiao,Lin, Jin-Hong,Xiao, Ji-Chang
-
supporting information
p. 16669 - 16673
(2017/12/07)
-
- Optically active helical polymers with pendent thiourea groups: Chiral organocatalyst for asymmetric michael addition reaction
-
This article reports a novel category of helical substituted polyacetylenes bearing pendant thiourea groups and showing remarkable asymmetric catalysis ability. Thiourea-based monomer and another chiral monomer underwent copolymerization, affording copoly
- Zhang, Haiyang,Yang, Wantai,Deng, Jianping
-
p. 1816 - 1823
(2015/07/02)
-
- Synthesis, molecular modeling, and biological evaluation of novel chiral thiosemicarbazone derivatives as potent anticancer agents
-
A series of new chiral thiosemicarbazones derived from homochiral amines in both enantiomeric forms were synthesized and evaluated for their in vitro antiproliferative activity against A549 (human alveolar adenocarcinoma), MCF-7 (human breast adenocarcinoma), HeLa (human cervical adenocarcinoma), and HGC-27 (human stomach carcinoma) cell lines. Some of compounds showed inhibitory activities on the growth of cancer cell lines. Especially, compound 17b exhibited the most potent activity (IC50 4.6 μM) against HGC-27 as compared with the reference compound, sindaxel (IC50 10.3 μM), and could be used as a lead compound to search new chiral thiosemicarbazone derivatives as antiproliferative agents.
- Ta?demir, Demet,Karakü?ük-Iyido?an, Aysegül,Ula?li, Mustafa,Ta?kin-Tok, Tu?ba,Oru?-Emre, Emine El?in,Bayram, Hasan
-
p. 177 - 188
(2015/03/04)
-
- Contrasting Reactivity of CS2 with Cyclic vs. Acyclic Amidines
-
The interaction between carbon dioxide (CO2) and amidines such as 1,8-diazabicyclo[5.4.0]undecane (DBU) has been extensively studied, but the reaction of isovalent CS2 with such bases has been largely ignored, apart from a single crystallography report. Acyclic acetamidines are cleaved by CS2 at room temperature to give an isothiocyanate and a thioacetamide. Because the pathway to that cleavage involves a rotation that is difficult for cyclic amidines, the reaction of CS2 with cyclic amidines produces an entirely different product: a cyclic carbamic carboxylic trithioanhydride structure. The path to that product involves sp3 C-H activation leading to the formation of a new C-C bond at a carbon α to the central carbon of the amidine group. Alkylation and ring-opening of the cyclic carbamic carboxylic trithioanhydride has also been demonstrated under ambient conditions.
- Ang, M. Trisha C.,Phan, Lam,Alshamrani, Aliyah K.,Harjani, Jitendra R.,Wang, Ruiyao,Schatte, Gabriele,Mosey, Nicholas J.,Jessop, Philip G.
-
p. 7334 - 7343
(2015/11/25)
-
- Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor
-
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has roles in the innate immune response, and also contributes to inflammatory disease. While the biological properties of MIF are closely linked to protein-protein interactions, M
- Spencer, Emma S.,Dale, Edward J.,Gommans, Aimée L.,Rutledge, Malcolm T.,Vo, Christine T.,Nakatani, Yoshio,Gamble, Allan B.,Smith, Robin A.J.,Wilbanks, Sigurd M.,Hampton, Mark B.,Tyndall, Joel D.A.
-
p. 501 - 510
(2015/04/27)
-
- ISOTHIOCYANATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
-
Provided herein are compositions of matter and pharmaceutical compositions thereof, for use in inhibiting the growth of various microbial pathogens, including bacteria, fungi, protozoa, and viral pathogens. Also provided herein are methods of treating microbial diseases/infections and cancer with the compositions. The compositions are additionally useful in wood preservation and food preservation by inhibition of microbial growth.
- -
-
Paragraph 0315; 0330
(2015/10/05)
-
- Microwave-assisted synthesis of alkyl thiocyanates
-
Microwave irradiation accelerated the reaction of t-alkyl, allyl, and benzyl halides with Zn(SCN)2 to afford thiocyanates in excellent yields and high selectivity with the formation of isothiocyanates only in minor proportions. Because thiocyanates are stable intermediates to thiols, the method also affords facile access to corresponding thiols.
- Bound, D. James,Bettadaiah,Srinivas
-
p. 1138 - 1144
(2013/03/28)
-
- Synthesis and spectroscopic analysis of substituted 2-aminothiazolines
-
2-Aminothiazolines can exist in two tautomeric species, amino and imino forms, which can theoretically exist as two stereoisomers. Several methods and techniques have been used to evaluate tautomeric process, but in this case 15N NMR spectrosco
- Ferreira, Renan B.,Tormena, Claudio F.,Almeida, Wanda P.
-
p. 186 - 190
(2013/05/22)
-
- Synthesis and evaluation of new guanidine-thiourea organocatalyst for the nitro-Michael reaction: Theoretical studies on mechanism and enantioselectivity
-
A new guanidine-thiourea organocatalyst has been developed and applied as bifunctional organocatalyst in the Michael addition reaction of diethyl malonate to trans-β-nitrostyrene. Extensive DFT calculations, including solvent effects and dispersion correc
- Shubina, Tatyana E.,Freund, Matthias,Schenker, Sebastian,Clark, Timothy,Tsogoeva, Svetlana B.
-
p. 1485 - 1498
(2012/10/29)
-
- A general and facile one-pot process of isothiocyanates from amines under aqueous conditions
-
A general and facile one-pot protocol for the preparation of a broad range of alkyl and aryl isothiocyanates has been developed from their corresponding primary amines under aqueous conditions. This synthetic process involves an in situ generation of a dithiocarbamate salt from the amine substrate by reacting with CS2 followed by elimination to form the isothiocyanate product with cyanuric acid as the desulfurylation reagent. The choice of solvent is of decisive importance for the successful formation of the dithiocarbamate salt particularly for highly electron-deficient substrates. This novel and economical method is suitable for scale-up activities.
- Sun, Nan,Li, Bin,Shao, Jianping,Mo, Weimin,Hu, Baoxiang,Shen, Zhenlu,Hu, Xinquan
-
experimental part
p. 61 - 70
(2012/04/04)
-
- Selectfluor F-TEDA-BF4 mediated thiocyanation or isothiocyanation of alcohols by in situ generation of [+SCN] under heterogeneous and neutral conditions
-
A convenient approach for thiocyanation of alcohols has been developed using ammonium thiocyanate as thiocyanating agent in the presence of a catalytic amount of Selectfluor F-TEDA-BF4 in aqueous acetonitrile. In this method various alcohols generally afforded the corresponding thiocyanates or isothiocyanates directly in good to high yield under heterogeneous and neutral conditions.
- Khazaei, Ardeshir,Rahmati, Sadegh,Khalafi-Nezhad, Ali,Saednia, Shahnaz
-
experimental part
p. 123 - 125
(2012/05/05)
-
- 2-Chloro-1-methylpyridinium iodide, an efficient reagent for the conversion of alcohols into alkyl thiocyanates both under solvent and solvent-free conditions
-
A new application of the Mukaiyama reagent for the simple phosphine-free conversion of alcohols into the corresponding alkyl thiocyanates is described. This transformation can be achieved either in acetonitrile or under solvent-free conditions and the products obtained in good to excellent yields. The solvent-free procedure described here is the first report on the solvent-free thiocyanation of alcohols.
- Mokhtari, Babak,Azadi, Roya,Mardani, Edris
-
experimental part
p. 491 - 493
(2012/02/01)
-
- Efficient preparation of isothiocyanates from dithiocarbamates using bromineless brominating reagent
-
For the first time, the crystal structure of a ditribromide reagent 1,1'-(ethane-1,2-diyl)dipyridinium bistribromide (EDPBT) has been determined. Utilizing this thiophilic bromineless brominating agent EDPBT, highly useful synthetic intermediates (alkyl and aryl isothiocyanates) have been achieved directly from dithiocarbamates. EDPBT can be easily prepared from readily available reagents. It has been used as a thiophilic reagent, and its thiophilicity dominates over its brominating ability for substrates amenable to bromination. This is a sustainable process for the preparation of isothiocyantes because the spent reagent can be recovered, regenerated, and reused. Copyright Taylor & Francis Group, LLC.
- Yella, Ramesh,Ghosh, Harisadhan,Murru, Siva,Sahoo, Santosh K.,Patel, Bhisma K.
-
experimental part
p. 2083 - 2096
(2010/08/19)
-
- Heterogeneous thiocyanation of benzylic alcohols and silyl and THP ethers, and deprotection of silyl and THP-ethers by [PCl3-n(SiO 2)n] (silphos)
-
Silicaphosphite (silphos), [PCl3-n(SiO2) n], as a heterogeneous phosphorous compound, catalyzes the thiocyanation of benzylic alcohols and silyl and THP ethers in the presence of I2 and NH4SCN in refluxing CH3CN. The produced silphos oxide byproduct can be easily separated by a simple filtration. Silphos is also used for the efficient and selective deprotection of silyl and THP-ethers to their corresponding alcohols. Copyright
- Iranpoor,Firouzabadi,Bahador,Jamalian
-
experimental part
p. 1972 - 1978
(2010/11/16)
-
- Asymmetric conjugate addition of carbonyl compounds to nitroalkenes catalyzed by chiral bifunctional thioureas
-
Readily available chiral thioureas derived from cyclohexane-1,2-diamine were prepared and found to be highly effective organocatalysts for the conjugate addition of aldehydes and ketones to nitroalkenes. Excellent enantioselectivities and yields were obtained for a variety of aryl and heteroaryl nitroalkenes. The base additives are essential for good yields and excellent enantioselectivities in this transformation. Based on new experimental evidence, a modified catalytic mechanism was proposed to rationalize the important role of the base additives.
- Zhang, Xue-jing,Liu, Sheng-ping,Lao, Jin-hua,Du, Guang-jian,Yan, Ming,Chan, Albert S.C.
-
experimental part
p. 1451 - 1458
(2009/10/23)
-
- Highly efficient and catalyst-free synthesis of unsymmetrical thioureas under solvent-free conditions
-
A highly efficient and simple synthesis of unsymmetrical thioureas is reported based on the reaction of readily synthesized dithiocarbamates with amines, without using any catalyst under solvent-free conditions. The short reaction time, high yields, and s
- Halimehjani, Azim Ziyaei,Pourshojaei, Yaghoub,Saidi, Mohammad R.
-
scheme or table
p. 32 - 34
(2009/04/10)
-
- Synthesis and antitumor activity of optically active thiourea and their 2-aminobenzothiazole derivatives: A novel class of anticancer agents
-
A novel series of optically active 2-aminobenzothiazole derivatives were synthesized by reaction of optically active amine (I) with thiophosgene to obtain optically active isothiocyanates (IIa-h) which on condensation with 4-fluoro-3-chloro aniline (III)
- Manjula,Malleshappa Noolvi,Vipan Parihar,Manohara Reddy,Ramani, Vijay,Gadad, Andanappa K.,Singh, Gurdial,Gopalan Kutty,Mallikarjuna Rao
-
experimental part
p. 2923 - 2929
(2009/09/30)
-
- Diethyl chlorophosphate: A mild and versatile reagent for the one-pot preparation of isothiocyanates from amines
-
A simple, efficient, and new method has been developed for the synthesis of isothiocyanates from amines. The reaction of a variety of aromatic and aliphatic amines with carbon disulfide in the presence of diethyl chlorophosphate as an efficient reagent proceeded effectively to afford the corresponding isothiocyanates in moderate yields. This method is easy, rapid, and moderate-yielding for the synthesis of isothiocyanates from amines. Georg Thieme Verlag Stuttgart.
- Kaboudin, Babak,Jafari, Ehsan
-
experimental part
p. 2683 - 2685
(2009/04/04)
-
- ISOTHIOCYANATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
-
Provided herein are compositions of matter and pharmaceutical compositions thereof, for use in inhibiting the growth of various microbial pathogens, including bacteria, fungi, protozoa, and viral pathogens. Also provided herein are methods of treating microbial diseases/infections and cancer with the compositions. The compositions are additionally useful in wood preservation and food preservation by inhibition of microbial growth.
- -
-
Page/Page column 67; 71-72
(2008/12/07)
-
- Isothiocyanates from tosyl chloride mediated decomposition of in situ generated dithiocarbamic acid salts
-
(Chemical Equation Presented) A facile and general protocol for the preparation of isothiocyanates from alkyl and aryl amines is reported. This method relies on a tosyl chloride mediated decomposition of a dithiocarbamate salt that is generated in situ by treatment of an amine with carbon disulfide and triethylamine. Utilizing this protocol, we have prepared 19-alkyl- and arylisothiocyanates in moderate to excellent yield.
- Wong, Rince,Dolman, Sarah J.
-
p. 3969 - 3971
(2008/02/01)
-
- A new method for the synthesis of isothiocyanates from dithiocarbamates or alkyl amines using chlorosilanes as decomposition reagents
-
A series of isothiocyanates were prepared in good yields by the decomposition of dithiocarbamates using chlorosilanes such as Me 3SiCl, Me2SiCl2, MeSiCl3, and SiCl4 as decomposition reagents. Alkyl isothiocyanates were obtained by a facile one-pot method in high yield from alkyl amines using these inexpensive decomposition reagents in the presence of a base. Copyright Taylor & Francis Group, LLC.
- Bian, Gaofeng,Qiu, Huayu,Jiang, Jianxiong,Wu, Jirong,Lai, Guoqiao
-
p. 503 - 508
(2007/10/03)
-
- Oxalic acid-catalyzed reaction of alcohols with NaSCN: The effects of additives NaI and i2
-
Oxalic acid-mediated conversion of alcohols to thiocyante and/or isothiocyanate is described. Aliphatic tertiary alcohols give isothiocyanate by the reaction with NaSCN in the presence of I2, whereas they give thiocyanate without it. Copyright
- Miyake, Hideyoshi,Nakao, Yuichi,Sasaki, Mitsuru
-
p. 1262 - 1263
(2008/02/05)
-
- Asymmetric organocatalysis with novel chiral thiourea derivatives: Bifunctional catalysts for the Strecker and nitro-Michael reactions
-
Novel bifunctional organocatalysts bearing both a thiourea moiety and an imidazole group on a chiral scaffold were synthesized and applied to the Strecker synthesis and nitro-Michael reaction. The addition of acetone to nitroolefins in the presence of these novel bifunctional organocatalysts gave enantioselectivities (up to 87 % ee) that are superior to those generated by the proline and/or homo-proline tetrazole catalysts described in the literature. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.
- Tsogoeva, Svetlana B.,Yalalov, Denis A.,Hateley, Martin J.,Weckbecker, Christoph,Huthmacher, Klaus
-
p. 4995 - 5000
(2007/10/03)
-
- Thiourea-based non-nucleoside inhibitors of HIV reverse transcriptase as bifunctional organocatalysts in the asymmetric Strecker synthesis
-
The potential of novel and known pyridyl thiourea derivatives (non-nucleoside inhibitors (NNI) of HIV reverse transcriptase) as bifunctional organic catalysts in the asymmetric Strecker synthesis was investigated. It was shown that incorporation of the im
- Tsogoeva, Svetlana B.,Hateley, Martin J.,Yalalov, Denis A.,Meindl, Kathrin,Weckbecker, Christoph,Huthmacher, Klaus
-
p. 5680 - 5685
(2007/10/03)
-
- A one-pot preparation of isothiocyanates from amines using two phosgene substitutes: bis-(trichloromethyl) carbonate and trichloromethyl chloroformates
-
A series of isothiocyanates have been prepared in high yields in a one-pot reaction from commercial amines and carbon disulfide under mild conditions using bis(trichloromethyl)carbonate (BTC) and trichloromethyl chloroformate (TCF) as reagents in the presence of base.
- Bian, Gaofeng,Shan, Weiguang,Su, Weike
-
p. 585 - 586
(2007/10/03)
-
- Modified guanidines as potential chiral superbases. 2. Preparation of 1,3-unsubstituted and 1-substituted 2-iminoimidazolidine derivatives and a related guanidine by the 2-chloro-1,3-dimethylimidazolinium chloride-induced cyclization of thioureas
-
Simple preparation methods for modified guanidines were explored for new chiral superbases. Thus, (4S,5S)-4,5-diphenyl- and diastereomeric cyclohexane-fused 2-iminoimidazolidines were prepared from (1S,2S) - 1,2 -diphenylethylenediamine and (1R,2R)- or (1S,2S)-1,2-diaminocyclohexanes through cyclization of protected thiourea intermediates with 2-chloro-1,3-dimethylimidazolinium chloride (DMC) as a key reaction. In the (4S,5S)-4,5-diphenyl series 1-methyl-2-iminoimidazolidines and 2-diethylaminoimidazoline were also prepared as related guanidines.
- Isobe,Fukuda,Tokunaga,Seki,Yamaguchi,Ishikawa
-
p. 7774 - 7778
(2007/10/03)
-
- A facile one-pot preparation of isothiocyanates from aldoximes
-
Isothiocyanates 2a-l were prepared in excellent yields in a one-pot reaction from aldoxime derivatives 1a-l by successive treatment of aldoxime with N-chlorosuccinimide (NCS), thiourea, and triethylamine. The use of HCl/DMF/Oxone system in the reaction instead of NCS was equally effective.
- Kim, Jae Nyoung,Jung, Keum Shin,Lee, Hong Jung,Son, Ji Suk
-
p. 1597 - 1598
(2007/10/03)
-
- A general synthesis of isothiocyanates from dithiocarbamates using claycop
-
A Convenient and simple synthesis of alkyl, aryl and amino acid isothiocyanates is described by the decomposition of ammonium dithiocarbamates using Claycop in mild conditions.
- Mesheram, Harashadas M.,Dale, Srinivas,Yadav
-
p. 8743 - 8744
(2007/10/03)
-
- The invention of radical reactions. Part XXVI. New thio- and seleno-hydroxamic acids; radical chemistry of their O-acyl derivatives
-
New thio- and seleno-hydroxamic acids have been synthesized from various 4,4-disubstituted thiazolidine 2,5-dithiones. Their corresponding O-acyl derivatives rearrange photochemically, with visible light, in an identical manner to the acyl derivatives of
- Barton,Tachdjian
-
p. 7091 - 7108
(2007/10/02)
-
- Phosphine-Substituted Chelate Ligands, XX. Synthesis and Diastereoselective Complexation of Chiral Phosphinothioformamides, Ph2P(X)C(S)NHHMePh (X = 2e(-), O, S)
-
The ambidentate chiral phosphinothioformamides (-)-S- and (+)-R-Ph2P(X)C(S)NHHMePh with X = 2e(-) (1a), O (1b), S (1c) were obtained from optically pure S- and R-1-phenylethylamine via the isothiocyanate intermediates.Coordination of (-)-1a to CpM(CO)3
- Kunze, Udo,Jawad, Hussain,Burghardt, Roland
-
p. 1142 - 1150
(2007/10/02)
-