- Design, synthesis, and photophysical characterization of novel pentacyclic red shifted azine dyes
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As part of our continuing efforts to develop second generation photodynamic therapeutic agents [1], we synthesized three pentacyclic azine dyes that were designed with the aid of MNDO calculations to absorb visible light having wavelengths longer than 600
- Gloster, Daniel F.,Cincotta, Louis,Foley, James W.
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- Synthesis of novel reactive disperse silicon-containing dyes and their coloring properties on silicone rubbers
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Novel red and purple reactive disperse silicon-containing dyes were designed and synthesized using p-nitroaniline and 6-bromo-2,4-dinitro-aniline as diazonium components, the first condensation product of cyanuric chloride and 3-(N,N-diethyl)amino-aniline
- Yu, Ning,Zhang, Shufen,Tang, Bingtao,Ma, Wei,Qiu, Jinjing
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- RESIN COMPOSITION, OPTICAL FILTER, IMAGE DISPLAY DEVICE, SOLID-STATE IMAGING ELEMENT, AND COLORANT MIXTURE
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Provided are a resin composition including a colorant and a resin, in which the colorant contains two or more squarylium colorants represented by Formula (1) below, at least one of the squarylium colorants is a squarylium colorant having a hydrogen-bonding group, which is represented by Formula (2) below, and a colorant mixture consisting of the two or more squarylium colorants, which is included in the resin composition, has a maximum absorption wavelength in a wavelength range of 400 nm to 700 nm; an optical filter; a liquid crystal display device; a solid-state imaging element; and a colorant mixture.
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Paragraph 0287; 0288
(2021/09/10)
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- Inter-alkane amidogen phenolic synthetic method (by machine translation)
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Inter-alkane amidogen phenolic synthetic method, its characteristic is: 1st step, between the two alkane amidogen acyl aniline and sulfuric acid aqueous solution mixing and heating to 50 - 110 °C, thermal insulation reaction of aniline [...] sulfuric acid aqueous solution; 2nd step, continue to drip the sodium nitrite aqueous solution, sodium nitrite aqueous solution for dropping temperature of - 10 - 20 °C, drop bi yu 5 - 30 °C insulation, [...] aniline obtained diazonium salt of the sulfuric acid aqueous solution; 3rd step, [...] aniline diazonium salt of the sulfuric acid aqueous solution is directly heated to 45 - 110 °C, thermal insulation, in the hydrolysis reaction of the diazonium salt, cooling after treatment, to obtain the product between two alkane amidogen phenol; three-step required by the reaction of sulfuric acid in the 1st step reaction in the finished disposable adding; a three-step reaction in a finish step by step in the pot. The method of the invention with raw materials are cheap, abundant, synthetic high security of the process, the product yield is high, the three waste less pollution and the like, has high industrial value. (by machine translation)
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Paragraph 0020
(2019/01/23)
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- PARTICLES FOR ELECTROPHORETIC DISPLAYS
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This invention relates to polymer particles preferably with surface functionality for charge retention, a process for their preparation, the use of these particles for the preparation of an electrophoretic device, electrophoretic displays comprising such particle, and new polymerisable dyes.
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Paragraph 0160; 0161
(2018/03/01)
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- DIARYLUREAS AS CB1 ALLOSTERIC MODULATORS
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The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.
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Paragraph 69; 126; 166
(2018/12/02)
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- Catalyst-Directed Chemoselective Double Amination of Bromo-chloro(hetero)arenes: A Synthetic Route toward Advanced Amino-aniline Intermediates
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A chemoselective sequential one-pot coupling protocol was developed for preparing several amino-anilines in high yield as building blocks for active pharmaceutical ingredients (APIs). Site (Cl vs Br on electrophile) and nucleophile (amine vs imine) selectivity is dictated by the catalyst employed. A Pd-crotyl(t-BuXPhos) precatalyst selectively coupled the Ar-Br of the polyhaloarene with benzophenone imine, even in the presence of a secondary amine, while Pd-based RuPhos or (BINAP)Pd(allyl)Cl coupled the Ar-Cl site with secondary amines.
- Mikhailine, Alexandre A.,Grasa Mannino, Gabriela A.,Colacot, Thomas J.
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supporting information
p. 2301 - 2305
(2018/04/30)
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- Discovery of Potent, Selective Stem Cell Factor Receptor/Platelet Derived Growth Factor Receptor Alpha (c-KIT/PDGFRα) Dual Inhibitor for the Treatment of Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs)
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Stem cell factor receptor (c-KIT) and platelet derived growth factor receptor alpha (PDGFRα) kinases play an important role in gastrointestinal stromal tumors (GISTs). Here, we have discovered an c-KIT/PDGFRα dual inhibitor, compound 31, with single-digit nanomolar potency against c-KIT and PDGFRα. Compared to Imatinib (1), 31 showed better antiproliferative efficacy against various TEL-c-KIT/PDGFRα-BaF3 isogenic cells, including three 1-resistant BaF3 cell lines, as well as against GIST-T1 and GIST-882 cell lines. Furthermore, compound 31 showed a good KinomeScan selectivity (468 kinases) (S score (1) = 0.01 at 1 μM concentration), good metabolic stability in liver microsomes, and no hERG inhibitory activity. It was worth noting that 31 inhibited GIST-T1 tumor growth (TGI = 81.5%) and even the BaF3-TEL-cKIT-T670I tumor progression (TGI = 41.9%, 1-resistant GISTs) at a dosage of 100 mg/kg/day without exhibiting apparent toxicity.
- Lu, Yanli,Mao, Fei,Li, Xiaokang,Zheng, Xinyu,Wang, Manjiong,Xu, Qing,Zhu, Jin,Li, Jian
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supporting information
p. 5099 - 5119
(2017/06/28)
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- COLORED CURABLE RESIN COMPOSITION
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The present invention provides a colored curable resin composition comprising: one or more kinds of colorants (A1) selected from the group of C.I. pigment yellow 138, a green pigment and a yellow pigment, Squarylium dye (A2), resin (B), polymer compounds
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Paragraph 0417-0419
(2016/11/24)
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- METAL FREE ACID DYES, PROCESS FOR THE PRODUCTION THEREOF AND THEIR USE
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The present invention relates to dyes of formula (1) a process for preparing them and their use for dyeing and printing hydroxyl- and/or carboxamido-containing materials.
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Page/Page column 81
(2014/07/07)
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- METAL FREE REACTIVE DYES, PROCESS FOR THE PRODUCTION THEREOF AND THEIR USE
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The present invention relates to reactive dyes of the formula (I) in which A, B, a and K are defined as given in claim, a process for preparing them, and their use for dyeing and printing hydroxyl-, amino-, and/or carboxamido-containing materials.
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Page/Page column 198; 199
(2014/01/09)
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- Antiprion activity of functionalized 9-aminoacridines related to quinacrine
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A library of functionalized 6-chloro-2-methoxy-(N9-substituted)acridin-9-amines structurally related to quinacrine were synthesized and evaluated for antiprion activity on four different cell models persistently infected with scrapie prion strains (ScN2a, N167, Ch2) or a human disease prion strain (F3). Most of the compounds were distinguished by the side chain attached to 9-amino of the acridine ring. These were dialkylaminoalkyl and phenyl with basic groups on the phenyl ring. The most promising compound was 6-chloro-2-methoxy-N-(4-(4-methylpiperazin-1-yl)phenyl)acridin-9-amine (15) which had submicromolar EC50 values (0.1-0.7 μM) on all cell models, was able to clear PrPSc at non-toxic concentrations of 1.2-2.5 μM, and was more active than quinacrine in terms of EC50 values. Other promising compounds were 14 (a regioisomer of 15) and 17 which had a 1-benzylpiperidin-4-yl substituent attached to the 9-amino function. Activity was strongly dependent on the presence of a substituted acridine ring, which in this library comprised 6-chloro-2-methoxy substituents on the acridine ring. The side chains of 14, 15, and 17 have not been previously associated with antiprion activity and are interesting leads for further optimization of antiprion activity.
- Nguyen Thi, Hanh Thuy,Lee, Chong-Yew,Teruya, Kenta,Ong, Wei-Yi,Doh-ura, Katsumi,Go, Mei-Lin
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p. 6737 - 6746
(2008/12/21)
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- Synthesis and NMR-spectral characterization of N,N-dialkyl-3-nitroanilines, N,N-dialkyl-1,3-benzenediamines and their acyl derivatives
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A recently discovered method for the synthesis of N,N-dialkyl-1,3-benzenediamines with two different alkyl groups is shown to be general.This is demonstrated by the synthesis of N-butyl-N-phenethyl-1,3-benzenediamine by the condensation of 3-nitroaniline with phenylacetaldehyde and benzotriazole, reduction of the adduct with sodium borohydride, acylation of the resulting N-phenethyl-3-nitroaniline with butyryl chloride, catalytic reduction of the nitro group by formic acid in the presence of triethylamine and palladium and finally reduction of the butyramide carbonyl group to the butyl substituent by lithium aluminium hydride.Several other routes were less efficient or failed completely.Classical methods for the synthesis of N,N-diethyl-1,3-benzenediamine were reexamined and improved.The recommended procedure involves alkylation of 3-nitroaniline with diethyl sulfate, trapping of N-ethyl-3-nitroaniline (by-product) by benzoylation, distillation of N,N-diethyl-3-nitro-aniline under reduced pressure and reduction of the nitro group by formic acid catalyzed by palladium.
- Katritzky, Alan R.,Rachwal, Bogumila,Rachwal, Stanislaw
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p. 337 - 345
(2007/10/02)
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- Synthesis and Spectral Characterization of Blue Dyes of the Benzene Series
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53 Donor-acceptor substituted azo dyes of the benzene series were prepared by diazonium-coupling reactions (1a-s) or halogen-cyanide exchange (->2a-x, 3a-j).Described are the preparation of the amines 4a-m and the coupling compounds 5a-t and the procedure of diazotizing and coupling.The colouristic and spectroscopic data show that compounds of the general formula 1 are excellent brilliant blue azo dyes usefull for dyeing polyester material.
- Thiel, W.,Mayer, R.,Jauer, E.-A.,Modrow, H.,Dost, H.
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p. 497 - 514
(2007/10/02)
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