- Synthesis method of fluorine-containing phenol structure compound
-
The invention discloses a synthesis method of a fluorine-containing phenol structure compound, and belongs to the technical field of chemical synthesis. Fluorine-containing benzoic acid is subjected to a one-pot reaction in a solvent under the action of alkali to obtain fluorine-containing phenate, and fluorine-containing phenol is obtained after acid regulation and dissociation. The synthesis method has the advantages of rich, cheap and easily available raw material structure, short synthesis steps, mild reaction conditions, simple and convenient operation, high synthesis yield, good productquality, wide application range and the like, and is suitable for simple and efficient synthesis of various high-value and high-purity fluorine-containing phenol compounds.
- -
-
Paragraph 0041-0042
(2021/03/13)
-
- Phenol compound ortho-position direct fluorination method
-
The invention relates to a phenol compound ortho-position direct fluorination method which comprises the following steps: reacting a phenol compound shown in a formula (1A) with a fluorination reagentin a solvent under the action of a photocatalyst and a light source at room temperature, and separating and purifying a reaction mixture after the reaction to obtain a fluorinated phenol compound shown in a formula (2A). The advantages are as follows: the method for directly fluorinating phenol by organic photocatalysis is simple in operation process; raw materials are commercialized and easy toobtain; the photocatalyst is low in price, easy to obtain and environmentally friendly; the reaction condition is mild; the site selectivity is high; the reaction is efficient; and a fluorinated phenol derivative can be prepared only through one step.
- -
-
Paragraph 0040-0042
(2020/04/17)
-
- Catalytic defluorination of perfluorinated aromatics under oxidative conditions using N-bridged diiron phthalocyanine
-
Carbon-fluorine bonds are the strongest single bonds in organic chemistry, making activation and cleavage usually associated with organometallic and reductive approaches particularly difficult. We describe here an efficient defluorination of poly- and perfluorinated aromatics under oxidative conditions catalyzed by the μ-nitrido diiron phthalocyanine complex [(Pc)Fe III(μ-N)FeIV(Pc)] under mild conditions (hydrogen peroxide as the oxidant, near-ambient temperatures). The reaction proceeds via the formation of a high-valent diiron phthalocyanine radical cation complex with fluoride axial ligands, [(Pc)(F)FeIV(μ-N)FeIV(F) (Pc+?)], which was isolated and characterized by UV-vis, EPR, 19F NMR, Fe K-edge EXAFS, XANES, and Kβ X-ray emission spectroscopy, ESI-MS, and electrochemical techniques. A wide range of per- and polyfluorinated aromatics (21 examples), including C6F6, C6F5CF3, C6F5CN, and C6F5NO2, were defluorinated with high conversions and high turnover numbers. [(Pc)FeIII(μ-N)Fe IV(Pc)] immobilized on a carbon support showed increased catalytic activity in heterogeneous defluorination in water, providing up to 4825 C-F cleavages per catalyst molecule. The μ-nitrido diiron structure is essential for the oxidative defluorination. Intramolecular competitive reactions using C6F3Cl3 and C6F3H 3 probes indicated preferential transformation of C-F bonds with respect to C-Cl and C-H bonds. On the basis of the available data, mechanistic issues of this unusual reactivity are discussed and a tentative mechanism of defluorination under oxidative conditions is proposed.
- Colomban, Cédric,Kudrik, Evgenij V.,Afanasiev, Pavel,Sorokin, Alexander B.
-
supporting information
p. 11321 - 11330
(2014/11/07)
-
- Trifluoromethanesulfonic acid: A novel solvent for the electrophilic fluorination of fluoroaromatics
-
Trifluoromethanesulfonic acid has been discovered to be an excellent new solvent for promoting the direct elemental fluorination of aromatics. Fluorobenzene has been successfully fluorinated to a mixture of 1,4-difluorobenzene (31%) and 1,2-difluorobenzene (7%) in CFCl3-CF3SO3H (5%), but no further improvement is observed by the addition of boron trifluoride. When the reaction is carried out in only CFCl3, the main reaction pathway is the 1,2- and 1,4-addition of fluorine to fluorobenzene forming cyclohexenes of molecular formula C6H5F5, and only a small amount of 1,4-difluorobenzene is produced. Although both 1,2- and 1,3-difluorobenzene are fluorinated to 1,2,4-trifluorobenzene in CFCl3-CF3SO3H (10%), 1,4-difluorobenzene does not undergo the same electrophilic substitution reaction.
- Coe, Paul L.,Stuart, Alison M.,Moody, David J.
-
p. 1807 - 1811
(2007/10/03)
-
- Cephalosporins
-
A syn isomer in (R) or (S) form or a mixture thereof of a compound of the formula STR1 syn isomer, in the (R) or (S) form or in the form of an (R,S) mixture, in the form of an internal salt or their salts with organic or mineral acids, wherein the variables are herein below defined, having antibacterial properties.
- -
-
-
- Cephalosporins
-
A syn isomer in (R) or (S) form or a mixture thereof of a compound of the formula STR1 in the form of an internal salt or a non-toxic, pharmaceutically acceptable acid addition salt wherein R1, R2, R3 and R5 are individually defined in the specification, R4 is --OH or alkoxy of 1 to 8 carbon atoms, A and A' are individually selected from the group consisting of hydrogen, an equivalent of an alkali metal or alkaline earth metal, magnesium, ammonium and an organic amine, or one or two of --COOA or --COOA' ARE --CO2 --, the wavy line means --CH2 R6 can be in the E or Z position, R6 in the quaternary ammonium form is selected from the group consisting of STR2 X is defined as in the specification with the proviso that when R3 is --OH or alkoxy of 1 to 8 carbon atoms, at least one R1, R2 and R5 is other than hydrogen having antibacterial properties.
- -
-
-