- Iodinated aroyloxy ketones
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Compounds having the structure STR1 wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 20; R1, R2, R3 and R4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, acylamino, acetamidoalkyl, acetamidoaryl, --COO-alkyl, --COO-aryl, --COO-aralkyl, --CO-alkyl, --CO-aryl, --CO-heterocyclyl, cyano or heterocyclyl; R5 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl, heterocyclyl, or a Z-CO2 -CR1 R2 (CR3 R4)n group, wherein Z, R1, R2, R3, R4 and n are as defined above, m is an integer from 0 to 10, p is an integer from 0 to 10, and m+p≥1 are useful as contrast agents in x-ray imaging compositions and methods.
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- Iodinated aromatic compounds
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Compounds having the structure STR1 wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 6; R1 and R2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy; R3 and R4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy or acylamino; Q represents the atoms necessary to complete a carbocyclic or heterocyclic unsaturated mono- or bicyclic aromatic ring; and R5 is H, alkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, amino, acylamino, alkoxyalkyl, fluoroalkyl, acetamidoalkyl, COO-alkyl, cyano, carboxamido, sulfonate, sulfonamido, ureido, or carbamyl are useful as contrast agents in x-ray imaging compositions and methods.
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- Polyiodinated aroyloxy esters
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Compounds having the structure STR1 wherein Z--COO)m is the residue of a polyiodinated aromatic acid; m is 1, 2, 3 or 4; n is an integer from 1 to 20; R1 and R2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy; R3 and R4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy or acylamino; and R5 is H, alkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; are useful as contrast agents in x-ray imaging compositions and methods.
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- Iodinated benzoyl acetals and ketals for x-ray imaging
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Compounds having the structure STR1 wherein (Z--COO is the residue of an iodinated aromatic acid; R is alkyl, cycloalkyl, aryl, aralkyl, STR2 or alkenyl; R1 is H, alkyl, cycloalkyl, aryl, aralkyl, or --CH2 --m CO2 R3 ; R2 is H, alkyl, cycloalkyl, aryl, aralkyl, --CH2 --n CO2 R4, or a STR3 group, wherein Z, R and R1 are as defined above; or R1 and R2, taken together with the carbon atom to which they are attached represent cycloalkyl; R3 is H, alkyl, cycloalkyl, aryl or aralkyl; R4 is H, alkyl, cycloalkyl, aryl or aralkyl; and m, n and p are independently an integer of from 0 to 17; provided that R1 and R2 can not both be H; are useful in the preparation of x-ray contrast compositions for medical imaging.
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- Iodinated wetting agents
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Compounds having the structure STR1 wherein (Z)--COO is the residue of an iodinated aromatic acid; M is H, a cation, --CH2 CH2 O--m H, and --CH2 CH(OH)O--p H; m is an integer from 1 to 150; p is an integer from 1 to 50; and L is one or more divalent linking groups selected from alkylene, cycloalkylene, arylene, arylenealkylene, and alkylenearylene are particularly useful as wetting agents in x-ray imaging compositions.
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- Iodinated aroyloxy esters
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Compounds having the structure STR1 wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 1 to 20; R1 and R2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy; R3 and R4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy or acylamino; and R5 is alkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; are useful as contrast agents in x-ray imaging compositions and methods.
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- Iodinated aromatic propanedioates
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Compounds having the structure STR1 where (Z--COO is the residue of an iodinated aromatic acid; R1 and R2 are independently alkyl, fluoroalkyl, cycloalkyl, aryl or aralkyl; and R3 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, cyano, sulfonate, carboxamido, sulfonamido, CO2 -alkyl, CO2 -aryl or CO2 -aralkyl; are useful as contrast agents in x-ray imaging compositions and methods.
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- Iodinated aroyloxy carboxamides
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Compounds having the structure STR1 wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 20; R1 and R2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy; R3 and R4 are independently a substituent as defined for R1 and R2 above, halogen, hydroxy or acylamino; and R5 and R6 are independently H, alkyl, cycloalkyl, aryl, aralkyl, alkoxy, alkoxyalkyl, or acetamidoalkyl; or R5 and R6, taken together with the nitrogen atom to which they are attached, represent a 4 to 7-membered nitrogen containing ring, are useful as contrast agents in x-ray imaging compositions and methods.
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- Non-ionic polyol contrast media from ionic contrast media
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Novel non-ionic contrast media of a hitherto unknown combination of low osmolality and low viscosity are efficiently prepared from generally available ionic contrast media or non-iodinated precursors. Particularly, polyhydroxyhalo-hydrocarbons are employed with a triiodo-substituted acylamido benzoic acids in aqueous weakly basic media to selectively substitute the amido nitrogen, followed by activation of the carboxyl group for amide formation.
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