28179-44-4 Usage
Description
IOXITALAMIC ACID, also known as a substituted 2,4,6-triiodobenzoic acid, is an organoiodine compound characterized by its white solid appearance. It features an acetylamino group at position 3 and a (2-hydroxyethyl)carbamoyl group at position 5, which contribute to its unique properties and applications.
Uses
Used in Medical Imaging:
IOXITALAMIC ACID is used as a contrast medium for enhancing the visualization of the cardiovascular system in various imaging techniques. Its application reason is to improve the clarity and accuracy of diagnostic procedures.
IOXITALAMIC ACID is used as an excellent contrast media for:
1. Ventriculography: For visualizing the ventricles of the brain, aiding in the diagnosis of hydrocephalus and other related conditions.
2. Radiculography: To examine the spinal nerve roots, which can help identify nerve compression or damage.
3. Lumbar Myelography: A procedure used to assess the lumbar region of the spinal cord, which can be useful in diagnosing spinal cord injuries or abnormalities.
4. X-rays of the Cardiovascular System: To provide a clear image of the heart and blood vessels, assisting in the detection of various cardiovascular diseases and conditions.
Originator
Oxilan,Cook Imaging Corporation
Manufacturing Process
3-Methoxycarboxyl-5-nitrobenzoic acid (25 g) was hydrogenated in methanol
(500 ml) using palladium oxide on charcoal (2.5 g 10%) at atmospheric
pressure. When the exothermic reaction was completed the catalyst was
fluttered off. After cooling the solution at -20°C for 2.5 h, 12.7 g of 3-amino-
5-methoxycarbonylbenzoic acid was isolated. An additional 6.5 g of it was
isolated by concentrating the mother liquor.The 3-amino-5-methoxycarbonylbenzoic acid (12.0 g) was suspended in water
(280 ml), dissolved by addition of concentrated hydrochloric acid (7.1 ml) and
glacial acetic acid (28.5 ml). At 60°-70°C NaICl2 solution (73 ml, 58.7 g
ICl/100 ml) was added dropwise while stirring in the course of about 3 h. The
reaction mixture was heated at 80°-90°C for additional 3 h while stirring.After cooling to room temperature the mother liquor was decanted and the
residue dissolved as ammonium salt in water (80 ml). The ammonium salt
was precipitated by adding ammonium chloride (2.4 g) and cooling to 0°C.
The ammonium salt was filtered off and dissolved in water (140 ml),
charcoaled twice at 80°C and the acid was precipitated at room temperature
by addition of hydrochloric acid and was filtered off. The crude product was
dissolved in ethyl acetate (100 ml) and the solution was washed 3 times with
hydrochloric acid (2 N). By evaporating the solvent, 19 g of 3-amino-5-
methoxycarbonyl-2,4,6-triiodobenzoic acid was isolated. Melting point 170°-
176°C.A mixture of 3-amino-5-methoxycarbonyl-2,4,6-triiodobenzoic acid (198 g)
and thionyl chloride (400 ml) was heated while stirring at 70°C for 16 h. The
solid material dissolved slowly. Thionyl chloride was evaporated in vacuo, the
residue dissolved in chloroform (1000 ml), the solution washed with water (80
ml each), twice with saturated sodium bicarbonate, then 5 times with 2 N
sodium hydroxide solution and finally with water to neutral. The solution was
dried with CaCl2 filtered and evaporated to dryness. The 3-amino-5-
methoxycarbonyl-2,4,6-triiodobenzoyl chloride was dried at 50°C in vacuo.
Yield: 203.0 g. Melting point 55°-60°C.To the 3-amino-5-methoxycarbonyl-2,4,6-triiodobenzoyl chloride (53.0 g) was
added acetic anhydride (106 ml). After stirring at room temperature for 20
min then insoluble material was filtered off (3-4 g). To the filtrate was added
concentrated sulfuric acid (0.3 ml) whereby a yellowish product started to
precipitate. The temperature reached about 50°C. The 3-acetamido-5-
methoxycarbonyl-2,4,6-triiodobenzoyl chloride was isolated after storing in
refrigerator overnight. Yield: 39.0 g. Melting point 210°-215°C.The 3-acetamido-5-methoxycarbonyl-2,4,6-triiodobenzoyl chloride was
dissolved in a mixture of dioxan and dimethylformamide. In the course of 2 h
this solution was added dropwise to a solution of ethanolamine and
triethylamine in dioxan. The stirring was continued. A sticky precipitate was
filtered off. The filtrate was evaporated to dryness in vacuo. The residue was
triturated with aqueous sodium bicarbonate, filtered off and mixed with first
fraction. The combined solids were then suspended in aqueous sodium
bicarbonate filtered off washed with water and dried in vacuo to give methyl
5-acetamido-2,4,6-triiodo-(N-β-hydroxyethyl)-isophthalamate.The methyl 5-acetamido-2,4,6-triiodo-(N-β-hydroxyethyl)-isophthalamate was
mixed with fresh distilled ethanolamine and stirred. The excess ethanolamine
was removed in vacuo at 50°-60°C. The residue was dissolved in water, and
charcoaled at pH 5.5. The crude product was precipitated with hydrochloric
acid (pH 0.5) and filtered after stirring at 0°C. 5-Acetamido-2,4,6-triiodo-(N-
β-hydroxyethyl)isophthalamic acid was suspended in ethanol and dissolved by
addition of concentrated ammonia. The ammonium salt started to precipitate
in the course and was isolated after stirring. The salt was dissolved in water,
filtered and the acid was precipitated with hydrochloric acid (pH 0.5). After
stirring the product was filtered off and dried in vacuo.
Therapeutic Function
Diagnostic aid
Check Digit Verification of cas no
The CAS Registry Mumber 28179-44-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,1,7 and 9 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 28179-44:
(7*2)+(6*8)+(5*1)+(4*7)+(3*9)+(2*4)+(1*4)=134
134 % 10 = 4
So 28179-44-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H11I3N2O5.Na/c1-4(19)17-10-8(14)5(11(20)16-2-3-18)7(13)6(9(10)15)12(21)22;/h18H,2-3H2,1H3,(H,16,20)(H,17,19)(H,21,22);/q;+1/p-1
28179-44-4Relevant articles and documents
Iodinated aroyloxy ketones
-
, (2008/06/13)
Compounds having the structure STR1 wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 20; R1, R2, R3 and R4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, acylamino, acetamidoalkyl, acetamidoaryl, --COO-alkyl, --COO-aryl, --COO-aralkyl, --CO-alkyl, --CO-aryl, --CO-heterocyclyl, cyano or heterocyclyl; R5 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl, heterocyclyl, or a Z-CO2 -CR1 R2 (CR3 R4)n group, wherein Z, R1, R2, R3, R4 and n are as defined above, m is an integer from 0 to 10, p is an integer from 0 to 10, and m+p≥1 are useful as contrast agents in x-ray imaging compositions and methods.
Polyiodinated aroyloxy esters
-
, (2008/06/13)
Compounds having the structure STR1 wherein Z--COO)m is the residue of a polyiodinated aromatic acid; m is 1, 2, 3 or 4; n is an integer from 1 to 20; R1 and R2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy; R3 and R4 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy or acylamino; and R5 is H, alkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; are useful as contrast agents in x-ray imaging compositions and methods.
Iodinated wetting agents
-
, (2008/06/13)
Compounds having the structure STR1 wherein (Z)--COO is the residue of an iodinated aromatic acid; M is H, a cation, --CH2 CH2 O--m H, and --CH2 CH(OH)O--p H; m is an integer from 1 to 150; p is an integer from 1 to 50; and L is one or more divalent linking groups selected from alkylene, cycloalkylene, arylene, arylenealkylene, and alkylenearylene are particularly useful as wetting agents in x-ray imaging compositions.
