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2827-56-7

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Plant Uptake and Metabolism of Nitrofuran Antibiotics in Spring Onion Grown in Nitrofuran-Contaminated Soil
Environmental pollution caused by the discharge of mutagenic and carcinogenic nitrofurans to the aquatic and soil environment is an emerging public health concern because of the potential in producing drug-resistant microbes and being uptaken by food crops. Using liquid chromatography-tandem mass spectrometry analysis and with spring onion (Allium wakegi Araki) as the plant model, we investigated in this study the plant uptake and accumulation of nitrofuran from a contaminated environment. Our study revealed for the first time high uptake and accumulation rates of nitrofuran in the edible parts of the food crop. Furthermore, results indicated highly efficient plant metabolism of the absorbed nitrofuran within the plant, leading to the formation of genotoxic hydrazine-containing metabolites. The results from this study may disclose a previously unidentified human exposure pathway through contaminated food crops.
Wang, Yinan,Chan, K. K. Jason,Chan, Wan
p. 4255 - 4261
(2017/06/07)

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Nitrofurantoin

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Chemical Properties

Appearance/Colour :Pale yellow powder
Melting Point: 201-205 °C(lit.)
Boiling Point: 256.8 °C at 760 mmHg
Flash Point:109.1 °C
Solubility:DMSO (Slightly), Methanol (Slightly, Heated)
Storage Temp.:0-6°C
Vapor Pressure: 0.0119mmHg at 25°C
BRN: 3699376
PSA: 75.43000
LogP: 0.18090

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