2827-56-7 Usage
Description
1-Aminohydantoin hydrochloride is a pale yellow powder that serves as a vital reactant in the synthesis of various pharmaceutical compounds. It is a metabolite of Nitrofuran and is known for its significant role in the production of different drugs and chemical compounds.
Uses
1. Used in Pharmaceutical Synthesis:
1-Aminohydantoin hydrochloride is used as a reactant for the synthesis of various pharmaceutical compounds, including ectoparasiticidal drugs, skeletal muscle relaxants, and others. Its chemical properties make it a suitable candidate for creating a wide range of medications.
2. Used in Suzuki-Miyaura Coupling:
In the field of organic chemistry, 1-Aminohydantoin hydrochloride is utilized as a reactant for Suzuki-Miyaura coupling, a widely used method for the formation of carbon-carbon bonds, particularly in the synthesis of complex organic molecules.
3. Used in Lymphoid Specific Tyrosine Phosphatase Inhibition:
1-Aminohydantoin hydrochloride is employed as a reactant for the development of inhibitors targeting lymphoid-specific tyrosine phosphatase, an enzyme with potential implications in the treatment of autoimmune diseases and other conditions.
4. Used in Proteasome Inhibition by Peptide Semicarbazones:
1-Aminohydantoin hydrochloride is also used in the synthesis of peptide semicarbazones, which are known to inhibit the proteasome, a cellular protein degradation system. Inhibition of the proteasome can be beneficial in the treatment of certain cancers and other diseases.
5. Used in the Synthesis of Specific Compounds:
1-Aminohydantoin hydrochloride may be used as one of the reactants in the synthesis of specific compounds such as (E)-1-(2-hydroxybenzylideneamino)imidazolidine-2,4-dione and dantrolene, which includes dantrolene sodium, a medication used to treat malignant hyperthermia and muscle spasms.
Check Digit Verification of cas no
The CAS Registry Mumber 2827-56-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,8,2 and 7 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2827-56:
(6*2)+(5*8)+(4*2)+(3*7)+(2*5)+(1*6)=97
97 % 10 = 7
So 2827-56-7 is a valid CAS Registry Number.
InChI:InChI=1/C3H5N3O2.ClH/c4-6-1-2(7)5-3(6)8;/h1,4H2,(H,5,7,8);1H
2827-56-7Relevant articles and documents
Plant Uptake and Metabolism of Nitrofuran Antibiotics in Spring Onion Grown in Nitrofuran-Contaminated Soil
Wang, Yinan,Chan, K. K. Jason,Chan, Wan
, p. 4255 - 4261 (2017/06/07)
Environmental pollution caused by the discharge of mutagenic and carcinogenic nitrofurans to the aquatic and soil environment is an emerging public health concern because of the potential in producing drug-resistant microbes and being uptaken by food crops. Using liquid chromatography-tandem mass spectrometry analysis and with spring onion (Allium wakegi Araki) as the plant model, we investigated in this study the plant uptake and accumulation of nitrofuran from a contaminated environment. Our study revealed for the first time high uptake and accumulation rates of nitrofuran in the edible parts of the food crop. Furthermore, results indicated highly efficient plant metabolism of the absorbed nitrofuran within the plant, leading to the formation of genotoxic hydrazine-containing metabolites. The results from this study may disclose a previously unidentified human exposure pathway through contaminated food crops.
