- TOPICAL TREATMENT OF SOLID TUMORS AND OCULAR NEOVASCULARIZATION
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A topical method for treating various cancers, including cervical cancer, macular degeneration, melanoma and other skin cancers, by topical administration of a pharmaceutical composition comprising: formula (I) wherein X = O or S, Y is -OR4, -NHR4, -NHAc, -NHAIa, -NHSer, -NHGIu, -NHLys, -NHSuc, -NH(nitro)Arg, -NH(O)COR4, -NH(O)NHR4, -COOR4, where R4 is H, C1-6 alkyl, phenyl, benzyl or phosphate; R1 is selected from -OR, -NRR, and -SR where R is independently H, C1-6 alkyl, phenyl, or benzyl; R2 is selected from H or C1-6 alkyl; and R3 is H, -OH, or -OR5 where R5 is C1-6 alkyl, phenyl or benzyl or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.
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(2008/06/13)
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