284019-34-7

Basic information

• Product Name: Denibulin
• Synonyms: DENIBULIN;[5-[[4-[[(2S)-2-Amino-1-oxopropyl]amino]phenyl]thio]-1H-benzimidazol-2-yl]carbamic acid methyl ester;Unii-K7037m241u;(S)-methyl (5-((4-(2-aminopropanamido)phenyl)thio)-1H-benzo[d]imidazol-2-yl)carbamate hydrochloride;CarbaMic acid, [5-[[4-[[(2S)-2-aMino-1-oxopropyl]aMino]phenyl]thio]-1H-benziMidazol-2-yl]-, Methyl ester;MN029;Denibulin, >=98%;GAOHLWCIAJNSEE-JTQLQIEISA-N
• CAS NO: 284019-34-7
• Molecular Formula: C18H19N5O3S
• Molecular Weight: 385.44
• Mol File: 284019-34-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.42
• PKA: 10.55±0.10(Predicted)
• CAS DataBase Reference: Denibulin(CAS DataBase Reference)
• NIST Chemistry Reference: Denibulin(284019-34-7)
• EPA Substance Registry System: Denibulin(284019-34-7)

Safety Data

• Hazardous Substances Data: 284019-34-7(Hazardous Substances Data)

Usage

Uses

Treatment of solid tumors.

Upstream product

• 284019-53-0 methyl [5(6)-(4-(Nαtert-butoxycarbonylalanylamino)phenylthio)-1H-benzimidazol-2yl]carbamate 

Relevant articles and documents

TOPICAL TREATMENT OF SOLID TUMORS AND OCULAR NEOVASCULARIZATION

A topical method for treating various cancers, including cervical cancer, macular degeneration, melanoma and other skin cancers, by topical administration of a pharmaceutical composition comprising: formula (I) wherein X = O or S, Y is -OR4, -NHR4, -NHAc, -NHAIa, -NHSer, -NHGIu, -NHLys, -NHSuc, -NH(nitro)Arg, -NH(O)COR4, -NH(O)NHR4, -COOR4, where R4 is H, C1-6 alkyl, phenyl, benzyl or phosphate; R1 is selected from -OR, -NRR, and -SR where R is independently H, C1-6 alkyl, phenyl, or benzyl; R2 is selected from H or C1-6 alkyl; and R3 is H, -OH, or -OR5 where R5 is C1-6 alkyl, phenyl or benzyl or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof.