- Synthesis and insecticidal evaluation of aryl pyrazole 5-fluorouracil compounds
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Twenty eight aryl pyrazole derivatives containing 5-fluorouracil were designed and synthesised via the key intermediate 1-aryl-3-methyl-1H-pyrazole-5- carboxylic acid. The structures of target compounds were confirmed by 1H NMR, FT-IR, EA and t
- Chen, Yue,Fu, Xiao-Dong,Mu, Hai-Ping,Qin, Xiao-Fei,Wan, Rong
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p. 272 - 279
(2014/06/09)
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- Microwave-assisted synthesis of tetrazolyl pyrazole amides
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A rapid and efficient microwave-assisted synthesis N-(1H-tetrazol-5-yl) derivatives of 3-methyl-1-phenyl-1H-pyrazole- 5-carboxamide is described. These tetrazole pyrazole amides have interesting bacteriocidal, pesticidal, herbicidal and antimicrobial activities. They were identified by IR and 1H NMR elemental analyses. The target compounds were obtained in a shorter reaction time compared to conventional heating methods.
- Hu, Jun,Wang, Jikui,Zhou, Taoyu,Xu, Yanhua
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p. 525 - 527
(2011/11/30)
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- AMIDE COMPOUNDS AND MEDICINAL USE THEREOF
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The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.
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