- Method for preparing m-position functionalized pyridine compound
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The method comprises S1, preparation 1, 4 -dihydropyridine: in a glove box filled with nitrogen, a catalyst is sequentially added into the reaction bottle. The solvents, such as borane and pyridine were stirred, stirred, at 40 - 110 °C, and reacted 5 - 12
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Paragraph 0033-0035
(2021/10/27)
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- PHOSPHINE-BASED COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME
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A phosphine-based compound and an organic electroluminescence device including the same, the phosphine-based compound being represented by the following Formula 1:
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Paragraph 0148; 0149
(2019/02/02)
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- Synthesis and characterization of hydrophilic theophylline base compounds and their use as ligands in the microwave assisted Suzuki-Miyaura couplings of halopyridines in water Dedicated to the memory of Prof. Dr. Armando Cabrera Ortiz pioneer of Catalysis in Mexico. Great Researcher but above all a Great Human Being
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Xanthine derivatives, caffeine (L1), theobromine (L2), theophylline (L3), 7-(β-hydroxyethyltheophylline) (L4), (7-(2,3-dihydroxypropyl)theophylline) (L5), and theophylline 7-acetic acid (L6) and the acetylated derivatives of the later three (L7-L9) were employed as ligands for the in situ palladium catalyzed Suzuki-Miyaura cross couplings of a series of halogenated pyridines. Optimized conditions were found where the diacetylated ligand (L8) was determined to be the best for this process, producing good to excellent yields in the couplings of halogenated anilines with phenylboronic acid under mild reaction conditions in water using microwave irradiation.
- Conelly-Espinosa, Patricia,Toscano, Ruben A.,Morales-Morales, David
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p. 5841 - 5845
(2015/01/09)
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- Annulation of ketones with vinamidinium hexafluorophosphate salts: an efficient preparation of trisubstituted pyridines.
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alpha-Aryl ketones react with vinamidinium hexafluorophosphate salts to give access to the corresponding 3-arylpyridines. The annulation reactions proceed in good to excellent yields with vinamidinium salts containing electron-withdrawing groups at the beta-position (R(2)). The reaction was applied to the preparation of the COX-2 specific inhibitor 5-chloro-3-(4-methylsulfonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine (1), as well as a series of analogues.
- Marcoux,Corley,Rossen,Pye,Wu,Robbins,Davies,Larsen,Reider
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p. 2339 - 2341
(2007/10/03)
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