292068-12-3

Basic information

• Product Name: 3-CHLORO-5-PHENYLPYRIDINE
• Synonyms: 3-CHLORO-5-PHENYLPYRIDINE
• CAS NO: 292068-12-3
• Molecular Formula: C₁₁H₈ClN
• Molecular Weight: 189.64
• Mol File: 292068-12-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 303.1 °C at 760 mmHg
• Flash Point: 165.6 °C
• Appearance: /
• Density: 1.186g/cm³
• Vapor Pressure: 0.00171mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 3-CHLORO-5-PHENYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-5-PHENYLPYRIDINE(292068-12-3)
• EPA Substance Registry System: 3-CHLORO-5-PHENYLPYRIDINE(292068-12-3)

Safety Data

• Hazardous Substances Data: 292068-12-3(Hazardous Substances Data)

Usage

General Description

3-Chloro-5-phenylpyridine is a chemical compound with the molecular formula C11H8ClN. It is a derivative of pyridine and is classified as a chloropyridine. This chemical is commonly used as a building block in organic synthesis and pharmaceutical research, where it serves as a starting material for the production of various pharmaceuticals and agrochemicals. It is also used as a reagent in the synthesis of other complex organic compounds. 3-Chloro-5-phenylpyridine is known to have some potential health hazards, such as skin and eye irritation, and should be handled with care in a controlled laboratory setting.

InChI:InChI=1/C11H8ClN/c12-11-6-10(7-13-8-11)9-4-2-1-3-5-9/h1-8H

Upstream product

• 2457-47-8 3,5-dichloropyridine 
• 98-80-6 phenylboronic acid 
• 1008-88-4 3-phenylpyridine 
• 122-78-1 phenylacetaldehyde 

Downstream Products

• 1192191-36-8 C₂₁H₂₇N₃O₂ 
• 1008-88-4 3-phenylpyridine 

Relevant articles and documents

Method for preparing m-position functionalized pyridine compound

The method comprises S1, preparation 1, 4 -dihydropyridine: in a glove box filled with nitrogen, a catalyst is sequentially added into the reaction bottle. The solvents, such as borane and pyridine were stirred, stirred, at 40 - 110 °C, and reacted 5 - 12

Synthesis and characterization of hydrophilic theophylline base compounds and their use as ligands in the microwave assisted Suzuki-Miyaura couplings of halopyridines in water Dedicated to the memory of Prof. Dr. Armando Cabrera Ortiz pioneer of Catalysis in Mexico. Great Researcher but above all a Great Human Being

Xanthine derivatives, caffeine (L1), theobromine (L2), theophylline (L3), 7-(β-hydroxyethyltheophylline) (L4), (7-(2,3-dihydroxypropyl)theophylline) (L5), and theophylline 7-acetic acid (L6) and the acetylated derivatives of the later three (L7-L9) were employed as ligands for the in situ palladium catalyzed Suzuki-Miyaura cross couplings of a series of halogenated pyridines. Optimized conditions were found where the diacetylated ligand (L8) was determined to be the best for this process, producing good to excellent yields in the couplings of halogenated anilines with phenylboronic acid under mild reaction conditions in water using microwave irradiation.