- Synthesis of Some New Polyfunctionalized Pyridines
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5-Methyl-2,4-dihydro-3H-pyrazol-3-one and/or 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one was reacted with arylidenemalononitrile in the presence of sodium alkoxide to give 2-amino-6-alkoxy-4-arylpyridine-3,5-dicarbonitrile 4a–e instead of the reported pyrazolo[3,4-b]pyridine-5-carbonitriles. The same products 4a–e were prepared via reaction of arylidenemalononitrile with sodium alkoxide in an appropriative alcohol. However, the new synthetic route for preparation of their positional isomer 4-amino-6-alkoxy-2-arylpyridine-3,5-dicarbonitrile 7a–j has been achieved via reaction of 2-aminoprop-1-ene-1,1,3-tricarbonitrile with different aromatic aldehydes under the same conditions.
- Amer
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supporting information
p. 297 - 301
(2017/11/27)
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- Reusable Ce-V Loaded Alumina Catalyst for Multicomponent Synthesis of Substituted Pyridines in Green Media
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Ce-V/Al2O3 as an effective heterogeneous catalyst is synthesized by a simple technique. The catalyst was identified by powder X-ray diffraction, SEM, TEM, and BET surface area analysis. The catalyst is fully recyclable and reusable for several runs preser
- Maddila, Suresh,Maddila, Surya N.,Jonnalagadda, Sreekantha B.,Lavanya, Palakondu
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p. 658 - 664
(2016/04/19)
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- Transformation of 2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitrile into 4-aminopyrido[2,3-d]pyrimidines and 2-(pyrid-2-yl)guanidines
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The reactions of 2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitrile (14) with a range of primary and secondary amines are investigated. Treatment with n-BuNH2 and BnNH2 gave 1,3-di-n-butyl- and 1,3-dibenzyl-2-(3,5-dicyano-6-ethoxy-4-phenylpyrid-2-yl)guanidines 15a (32%) and 15b (82%), respectively. While treatment with Et2NH, n-Pr2NH or Bn2NH gave the analogous 4-dialkylaminopyrido[2,3-d]pyrimidines 16c-e in high yields. Treatment of the dithiazole 14 with pyrrolidine, piperidine or morpholine gave the analogous 4-dialkylaminopyrido[2,3-d]pyrimidines 16f-h, the 2-aminopyridine 13 and 2-(diamino-1-ylmethyleneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitriles 15f-h. The 4-dialkylaminopyrido[2,3-d]pyrimidines 16f-h are converted to the 2-(dialkylamino-1-ylmethyleneamino)-6-ethoxy-4-phenylpyridine-3,5-dicarbonitriles 15f-h upon further reaction with excess dialkylamines. The structure and origins of the two side products 17 and 18 are also discussed. Tentative mechanisms for these transformations are proposed.
- Kalogirou, Andreas S.,Michaelidou, Sophia S.,White, Andrew J.P.,Koutentis, Panayiotis A.
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p. 1799 - 1807
(2015/03/04)
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- A facile one-pot synthesis of 2-thioxo-dihydropyrimidines and polyfunctionalized pyran derivatives as mimics of novel calcium channel modulators
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An efficient protocol for the synthesis of pharmacologically significant dihydropyrimidines and polyfunctionalized pyrans is described by performing a one-pot multicomponent reaction (MCR). A chemistry-driven drug discovery approach is implemented by keep
- Yadlapalli, Rama Krishna,Chourasia,Perali, Ramu Sridhar
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supporting information
p. 6725 - 6728
(2013/01/15)
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- Multi-component synthesis of 6-alkoxy-2-amino-3,5-dicyanopyridines
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An efficient one-pot synthesis of mono- and bis-6-alkoxy-2-amino-3,5- dicyanopyridines via a four or pseudoseven-component reaction of aldehyde, malononitrile and alcohol using K2CO3 as the base is described.
- Karimi, Ali R.,Khodadadi, Azam
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experimental part
p. 422 - 426
(2012/08/28)
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- Synthesis and pharmacological activity of some nitrofuraldehyde cyanopyridine derivatives
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Compounds 3a-f were obtained by condensing 5-nitrofuraldehyde hydrazone with five iminoethers derived from the 6-alkoxy-(or alkylamino-)2-amino-4-aryl-3,5-dicyanopyridines. Tests of their antimicrobial activity against 16 micro-organisms showed that 3a (R
- Castedo,Quintela,Riguera
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p. 555 - 557
(2007/10/02)
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