Synthesis and biological evaluation of a series of (Benzo[d]thiazol-2-yl) cyclohexanecarboxamides and (Benzo[d]thiazol-2-yl)cyclohexanecarbothioamides
A series of benzothiazole derivatives including N-(benzo[d]thiazol-2-yl) cyclohexanecarboxamides (2a-g) and N-(benzo[d]thiazol-2-yl) cyclohexancarbothioamides (3b-d) have been synthesized and evaluated for cytotoxic and antimicrobial activities. Two compo
Synthesis and biological evaluation of benzothiazole derivatives as potent antitumor agents
Based on 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid[2- (cyclohexanecarbonylamino)benzothiazol-6-yl]amide (1), which shows selective cytotoxicity against tumorigenic cell lines, 2,6-dichloro-N-[2- (cyclopropanecarbonylamino)benzothiazol-6-yl]benzamide (13b) was designed and synthesized as a biologically stable derivative containing no nitro group. The highly potent derivative 13b exhibited excellent in vivo inhibitory effect on tumor growth.