- Novel Structural Hybrids of Pyrrole and Thiazole Moieties: Synthesis and Evaluation of Antibacterial and Antifungal Activities
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One of the best ways to design new biocidal agents is synthesizing hybrid molecules by combining two or more bioactive moieties in a single molecular scaffold. So, new series of pyrroles bearing a thiazole moiety were synthesized using 1-methyl-1H-pyrrole-2-carbaldehyde thiosemicarbazones 1a–c. Cyclization of thiosemicarbazone derivatives 1a–c with ethyl chloroacetate, ethyl 2-chloropropanoate, chloroacetone and phenacyl bromide afforded the corresponding thiazolidin-4-ones 2a–c, 5-methylthiazolidin-4-ones 3a–c, 4-methyl-2,3-dihydrothiazoles 4a–c, and 4-phenyl-2,3-dihydrothi-azoles 5a–c, respectively. The antimicrobial activity of the new thiazole derivatives was evaluated.
- Abbas, Samir Y.,Ali, Tarik E.,Assiri, Mohammed A.,El-Sharief, Marwa A. M. Sh,Gouda, Moustafa A.,Helal, Mohamed H.,Salem, Mohamed A.
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p. 990 - 996
(2021/12/29)
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