- Substituted pyrazolopyridine derivatives and medicinal use thereof
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The invention relates to substituted pyrazolopyridine derivatives represented by formula (I), and pharmaceutically acceptable salts, isomers, prodrugs and medicinal compositions thereof. Above compounds are stimulants of soluble guanylate cyclase. In the formula (I), R1 represents a thienyl group or a substituted pyridyl group, R2 represents -NH2, -NHCH3 or -NHC(=O)CH(CH3)2, R3 represents hydrogenor a C1-C4 alkyl group, and R4 represents a C1-C6 alkyl group. The invention also discloses a preparation method of the compounds and an application of the compounds as medicines, especially an application as cardiovascular disease treatment medicines, such as anti-pulmonary arterial hypertension medicines.
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- Substituted purinon derivatives and medicinal use thereof
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The invention relates to substituted purinon derivatives represented by formula (I), and pharmaceutically acceptable salts, isomers, prodrugs and medicinal compositions thereof. Above compounds are stimulants of soluble guanylate cyclase. In the formula (I), R1 represents a thienyl group or a substituted pyridyl group, R2 represents -NH2 or -NHCH3, and R3 represents hydrogen or a C1-C4 alkyl group. The invention also discloses a preparation method of the compounds and an application of the compounds as medicines, especially an application as cardiovascular disease treatment medicines.
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Paragraph 0073-0074
(2018/05/07)
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- Modular Route to Azaindanes
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A convergent radical based route to azaindanes is described, relying on the degenerative addition transfer of various substituted S-(pyridylmethyl)-O-ethyl dithiocarbonates (xanthates) to functional alkenes followed by radical cyclization onto the pyridine ring activated by protonation with trifluoroacetic acid. In one case, a richly decorated cyclohepta[b]pyridine could be assembled swiftly by allowing the first adduct to N-phenylmaleimide to undergo addition to N-allylphthalimide prior to cyclization.
- Huang, Qi,Zard, Samir Z.
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p. 3895 - 3898
(2017/07/26)
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- 2-OXO-1-PYRROLIDINE DERIVATIVES
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The present invention concerns 2-oxo-1 -pyrrolidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
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Page/Page column 82
(2008/06/13)
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- Efficient pyridinylmethyl functionalization: Synthesis of 10,10-bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone (DMP 543), an acetylcholine release enhancing agent
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2-Fluoro-4-methylpyridine (3) is efficiently functionalized by chlorination, hydrolysis and methane-sulfonylation into the novel alkylating agent 7. This mesylate is used for the bisalkylation of anthrone under carefully defined conditions to prepare the cognition enhancer drug candidate 1. This process proceeds in up to 37% overall yield and is adaptable for large scale synthesis.
- Pesti,Huhn,Yin,Xing,Fortunak,Earl
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p. 7718 - 7722
(2007/10/03)
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