- Manganese-Catalyzed Dual-Deoxygenative Coupling of Primary Alcohols with 2-Arylethanols
-
Reported herein is a general and efficient dual-deoxygenative coupling of primary alcohols with 2-arylethanols catalyzed by a well-defined Mn/PNP pincer complex. This reaction is the first example of the catalytic dual-deoxygenation of alcohols using a non-noble-metal catalyst. Both deoxygenative homocoupling of 2-arylethanols (17 examples) and their deoxygenative cross-coupling with other primary alcohols (20 examples) proceeded smoothly to form the corresponding alkenes by a dehydrogenation and deformylation reaction sequence.
- Wang, Yujie,Shao, Zhihui,Zhang, Kun,Liu, Qiang
-
supporting information
p. 15143 - 15147
(2018/11/01)
-
- Azastilbenes: A cut-off to p38 MAPK inhibitors
-
Inhibitors with vicinal 4-fluorophenyl/4-pyridine rings on a five- or six-membered heterocyclic ring are known to inhibit the p38 mitogen-activated protein kinase (MAPK), which is a potential target for rheumatoid arthritis and several different types of cancer. Several substituted azastilbene-based compounds with vicinal 4-fluorophenyl/4-pyridine rings were designed using computational docking, synthesized, and evaluated in a cell-free radiometric p38α assay. The biochemical evaluation shows that the best inhibition (down to 110 nM) is achieved for azastilbene-based compounds having an isopropylamine substituent in the 2-position of the pyridine ring. The inhibition of p38 signaling in human breast cancer cells was observed for two of the compounds. The Royal Society of Chemistry 2013.
- Poon, Jia-Fei,Alao, John Patrick,Sunnerhagen, Per,Dinér, Peter
-
p. 4526 - 4536
(2013/08/23)
-
- Reliable and versatile synthesis of 2-aryl-substituted cinnamic acid esters
-
2-Aryl-substituted phosphono acetates can be readily synthesized by a four-step sequence from the respective arenes. Succeeding Horner-Wadsworth- Emmons olefinations provide stereoselectively the 2-aryl cinnamic acid esters even when sensitive moieties are involved. Georg Thieme Verlag Stuttgart.
- Ianni, Alen,Waldvogel, Siegfried R.
-
p. 2103 - 2112
(2008/02/02)
-
- Arylation of α-substituted diethyl methylphosphonates with π-complexes of haloarenes
-
Nucleophilic aromatic substitution of halogen in neutral and cationic π-complexes of haloarenes η6-(ArF)Cr(CO)3 and [η6-(ArHlg)FeCp]+[PF6]- (Hlg = F, Cl) by carbanions derived from α-substi
- Artamkina,Sazonov,Beletskaya
-
-
- Arylation of phosphoryl-stabilized carbanions with metal π-complexes of aryl chlorides and fluorides
-
The nucleophilic aromatic substitution of halogen in metal arene π-complexes η6-(ArF)Cr(CO)3 and [η6-(ArHal)FeCp]+[PF6]- (Hal = F,Cl) with phosphoryl-stabilized carbanions ZCH2P(
- Artamkina, Galina A.,Sazonov, Petr K.,Beletskaya, Irina P.
-
p. 4385 - 4387
(2007/10/03)
-
- A useful synthesis of diethyl 1-substituted vinylphosphonates
-
A variety of diethyl 1-substituted vinylphosphonates 8 has been conveniently synthesized by piperidine catalyzed decarboxylative condensation of 2-diethoxyphosphorylalkanoic acids and 2-diethoxyphosphorylalkenoic acids 7 with formaldehyde.
- Krawczyk,Koszuk,Bodalski
-
p. 1123 - 1128
(2007/10/03)
-
- Potential GABAB Receptor Antagonists. X* the Synthesis of Further Analogues of Baclofen, Phaclbfen and Saclofen
-
In an attempt to obtain new compounds with binding activity at the GABAB receptor site, we report the synthesis of 3-amino-2-arylpropanoic acids, and the sulfonic, phosphonic and hydroxamic acid analogues. In addition, we report the synthesis of the isomer of phaclofen, 3-amino-1-(4-chlorophenyl)-propylphosphonic acid, and the higher homologue of baclofen, 5-amino-2-(4-chlorophenyl)pentanoic acid.
- Prager, Rolf H.,Schafer, Karl
-
p. 813 - 823
(2007/10/03)
-
- A CONVENIENT PREPARATION OF α-PHOSPHONO ESTERS AND LACTONES VIA C-P BOND FORMATION
-
The reaction of ester and lactone enolates with diethyl phosphorochloridite, followed by air oxidation of the immediate reaction products, has proven to be a general alternative to the traditional Arbuzov synthesis of α-phosphono esters and lactones.
- Lee, Koo,Wiemer, David F.
-
-
- Copper(I) Salt-Mediated Arylation of Phosphinyl-Stabilized Carbanions and Synthetic Application to Heterocyclic Compounds
-
The copper-mediated reaction of phosphinyl-stabilized carbanions 2a-c with aryl halides 1a-i in DMF or HMPA produced (arylmethyl)phosphonates 3-11 in good yields.Similar treatment of N-(2-iodophenyl)- and N-(2-iodophenyl)-N-methyl-α-(diethoxyphosphinyl)ac
- Minami, Toru,Isonaka, Takeshi,Okada, Yoshiharu,Ichikawa, Junji
-
p. 7009 - 7015
(2007/10/02)
-
- Synthesis of α-Phosphono Lactones and Esters through a Vinyl Phosphate-Phosphonate Rearrangement
-
Upon treatment with base, the diethyl vinyl phosphate derivatives of five-, six-, and seven-membered-ring lactones undergo rearrangement to α-phosphono lactones in very good yields.Because the vinyl phosphates can be prepared in situ, these α-phosphono lactones can be obtained from the parent lactones in a one-flask protocol, making this methodology a convenient alternative to the traditional Arbuzov synthesis.An analogous reaction sequence can be used to prepare some α-phosphono esters, but yields are generally lower and the rearrangement becomes minimal with esters hindered at the β-position.
- Jackson, John A.,Hammond, Gerald B.,Wiemer, David F.
-
p. 4750 - 4754
(2007/10/02)
-