- Microwave-assisted one-step synthesis of fenamic acid hydrazides from the corresponding acids
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A facile and efficient method for synthesis of fenamic acid hydrazides from their acids in one-step reaction under microwave irradiation and solvent-free conditions was developed. Compared with the two-step conventional heating method, the process was simple, the reaction time was very short and the yields were almost quantitative.
- Aboul-Fadl, Tarek,Abdel-Aziz, Hatem A.,Kadi, Adnan,Bari, Ahmed,Ahmad, Pervez,Al-Samani, Tilal,Ng, Seik Weng
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experimental part
p. 3544 - 3551
(2011/06/25)
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- Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.
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This paper describes SAR studies involved in the transformation of the NSAID meclofenamic acid into potent and selective cyclooxygenase-2 (COX-2) inhibitors via neutralization of the carboxylate moiety in this nonselective COX inhibitor.
- Kalgutkar, Amit S,Rowlinson, Scott W,Crews, Brenda C,Marnett, Lawrence J
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p. 521 - 524
(2007/10/03)
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- FENAMATE 1,3,4-THIADIAZOLES AND 1,3,4-OXADIAZOLES AS ANTIINFLAMMATORY AGENTS
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The present invention is novel compounds which are 1,3,4-thiadiazoles and 1,3,4-oxadiazoles, and pharamaceutically acceptable acid addition or base salts thereof having activity as inhibitors of singly or together 5-lipoxygenase and cyclooxygenase, and pharmaceutical compositions or methods of use therefor.
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- TRIAZOLE DERIVATIVES OF FENAMATES AS ANTIINFLAMMATORY AGENTS
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The present invention is novel compounds which are 1,2,4-triazoles, derivatives of fenamates and pharmaceutically acceptable additions and base salts thereof, pharmaceutical compositions and methods of use thereof. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever, and the like
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- New esters of N arylanthranilic acids
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A series of acyloxy and alkyloxymethyl esters of meclofenamic, flufenamic and mefenamic acids has been synthesized and its antiinflammatory, analgesic and antipyretic activities have been compared with those of the corresponding acids and the methyl, β,γ isopropylidenedioxypropyl, and N,N diethylaminoethyl esters. The acyloxy and alkyloxymethyl esters are the most interesting compounds, because they possess pharmacological activity of the same order as that of the corresponding acids and a lower toxicity. The ethoxymethyl ester of N (2,6 dichloro m tolyl)anthranilic acid is presently under clinical investigation.
- Salimbeni,Manghisi,Magistretti
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p. 276 - 286
(2007/10/06)
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