- Deprotonation-Triggered Heavy-Halogen Migrations as a Key to the Structural Elaboration of 2,2 -Difluoro-1,3-benzodioxole
-
Although proton abstraction from the 4-position of 2,2-difluoro-1,3-benzodioxole occurs with exceptional ease, lithiation of the more-remote 5-position can only be brought about if no oxygen-adjacent site remains unoccupied. Thus, unlike 4-bromo-2,2-diflu
- Gorecka, Joanna,Leroux, Frederick,Schlosser, Manfred
-
-
Read Online
- Fluorodesulfurization of Thionobenzodioxoles with Silver(I) Fluoride
-
Difluorobenzodioxole is an important functional group found in both pharmaceuticals and agrochemicals. The late-stage introduction of this functional group is challenged by typical fluorination conditions of HF and strong oxidants. Here, we demonstrate that a range of difluorobenzodioxoles can be prepared from catechols in two steps through conversion into thionobenzodioxoles, followed by desulfurative fluorination with silver(I) fluoride. These mild reaction conditions are compatible with a variety of functional groups and enable access to a range of functionalized difluorobenzodioxoles.
- Newton, Josiah J.,Brooke, Alan J.,Duhamel, Bastian,Pulfer, Jason M.,Britton, Robert,Friesen, Chadron M.
-
p. 13298 - 13305
(2020/11/26)
-
- Synthesis method of (2,2-difluorobenzo[d][1,3]dioxy-5-yl)methanol
-
The invention discloses a preparation method of (2,2-difluorobenzo[d][1,3]dioxo-5-yl)methanol as a fine chemical intermediate. The method is simple and feasible, lower in cost, and suitable for preparing (2,2-difluorobenzo[d][1,3]dioxo-5-yl)methanol through industrial production.
- -
-
Paragraph 0042-0044
(2019/04/04)
-
- PROCESS FOR THE PREPARATION OF DERIVATIVES OF BENZODIOXOLE
-
The present invention relates to the process for preparing compounds of Formula I, Formula III and Formula V.
- -
-
Page/Page column 9-10
(2017/04/11)
-
- PROCESS FOR THE PREPARATION OF HALOGENATED DERIVATIVES OF AROMATIC ETHERS
-
The present invention relates to the process for the preparation of halogenated derivatives of aromatic ethers.
- -
-
Page/Page column 4
(2016/04/20)
-
- Process for the preparation of 5-bromo-2,2-difluorobenzo-(1,3)-dioxoles
-
Preparation of 5-bromo-2,2-difluoro-benzo[1,3]dioxole compounds (I) comprises reacting 2,2-difluoro-benzo[1,3]dioxole compounds (II) with bromine in the presence of at least two Friedel-Crafts catalysts, one of the catalyst being hydrogen fluoride. Preparation of 5-bromo-2,2-difluoro-benzo[1,3]dioxole compounds of formula (I) comprises reacting 2,2-difluoro-benzo[1,3]dioxole compounds of formula (II) with bromine in the presence of at least two Friedel-Crafts catalysts, one of the catalyst being hydrogen fluoride. R 1>1-4C alkyl, Br, Cl or F; and n : 0-1. [Image].
- -
-
Page/Page column 4
(2008/06/13)
-
- Process for preparing 5-bromo-2,2-difluorobenzo-1,3-dioxoles
-
The invention relates to a process for preparing 5-bromo-2,2-difluorobenzo-1,3-dioxoles and to the use thereof for preparing medicaments and crop protection agents.
- -
-
Page/Page column 2
(2008/06/13)
-
- Herbicidal benzodioxoles and benzodioxanes
-
Compounds of Formula I, and their N-oxides and agriculturally-suitable salts, are disclosed which are useful for controlling undesired vegetation STR1 wherein: STR2 T is O or S; W is a single bond, O, S or NR6 ; X is N or CH; Y is N or CH; Z is
- -
-
-
- Benzoheterocyclyl ketone hydrazone insecticides
-
Benzoheterocyclyl ketone hydrazones of the formula STR1 in which Y is methylene, difluoromethylene or oxygen and n is 0 or 1, compositions thereof and their use as insecticides are disclosed and exemplified.
- -
-
-