33070-32-5

Basic information

• Product Name: 5-Bromo-2,2-difluorobenzodioxole
• Synonyms: 5-BROMO-2,2-DIFLUORO-1,3-BENZODIOXOLE;5-BROMO-2,2-DIFLUORO-BENZO[1,3]DIOXOLE;5-BROMO-2,2-DIFLUOROBENZODIOXOLE;4-Bromo-1,2-[(difluoromethylene)dioxy]benzene~3,4-[(Difluoromethylene)dioxy]bromobenzene;5-Bromo-2,2-difluoro-1,3-benzodioxole, 97+%;3,4-[(difluoromethylene)dioxy]bromobenzene;4-bromo-1,2-[(difluoromethylene)dioxy]benzene;5-Bromo-2,2-difluoro-1,3-benzodioxole 98%
• CAS NO: 33070-32-5
• Molecular Formula: C₇H₃BrF₂O₂
• Molecular Weight: 237
• Product Categories: Heterocycles series
• Mol File: 33070-32-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 78-79°C 20mm
• Flash Point: >75°C
• Appearance: /
• Density: 1,74 g/cm3
• Vapor Pressure: 0.00187mmHg at 25°C
• Refractive Index: 1.4967
• Storage Temp.: Room temperature.
• Solubility: Miscible with hexane.
• BRN: 1425209
• CAS DataBase Reference: 5-Bromo-2,2-difluorobenzodioxole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2,2-difluorobenzodioxole(33070-32-5)
• EPA Substance Registry System: 5-Bromo-2,2-difluorobenzodioxole(33070-32-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36-41
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 33070-32-5(Hazardous Substances Data)

Usage

Uses

5-Bromo-2,2-difluoro-1,3- benzodioxole is used as a precursor in organic synthesis. It is used to prepare 5-bromo-2,2-difluoro-1,3-benzodioxole-4-carboxylic acid. It serves as an intermediate in active pharmaceutical ingredients, agrochemicals and in dyestuff field.

InChI:InChI=1/C12H10FN/c13-10-6-8-12(9-7-10)14-11-4-2-1-3-5-11/h1-9,14H

Upstream product

• 17345-77-6 1-bromo-3,4-dihydroxybenzene 
• 663934-04-1 (7-bromo-2,2-difluoro-1,3-benzodioxol-4-yl)triethylsilane 
• 663934-00-7 (2,2-difluoro-1,3-benzodioxol-4-yl)triethylsilane 
• 1583-59-1 2,2-difluoro-1,3-benzodioxole 
• 663934-09-6 (6-bromo-2,2-difluoro-1,3-benzodioxol-4-yl)triethylsilane 
• 7439-89-6 iron 

Downstream Products

• 503269-73-6 (2,2-difluoro-1,3-benzodioxol-5-yl)diphenylphosphane oxide 
• 503269-74-7 (2,2-difluoro-4-iodo-1,3-benzodioxol-5-yl)diphenylphosphane oxide 
• 503269-75-8 [4,4'-bis(2,2-difluoro-1,3-benzodioxol)-5,5'-diyl]bis(diphenylphosphane oxide) 
• 503538-69-0 (R)-(-)-5,5’-bis(diphenyl;phosphine)-2,2,2’,2’-tetrafluoro-4,4’-bi-1,3-benzodioxole 

Relevant articles and documents

Deprotonation-Triggered Heavy-Halogen Migrations as a Key to the Structural Elaboration of 2,2 -Difluoro-1,3-benzodioxole

Although proton abstraction from the 4-position of 2,2-difluoro-1,3-benzodioxole occurs with exceptional ease, lithiation of the more-remote 5-position can only be brought about if no oxygen-adjacent site remains unoccupied. Thus, unlike 4-bromo-2,2-diflu

Synthesis method of (2,2-difluorobenzo[d][1,3]dioxy-5-yl)methanol

The invention discloses a preparation method of (2,2-difluorobenzo[d][1,3]dioxo-5-yl)methanol as a fine chemical intermediate. The method is simple and feasible, lower in cost, and suitable for preparing (2,2-difluorobenzo[d][1,3]dioxo-5-yl)methanol through industrial production.

PROCESS FOR THE PREPARATION OF HALOGENATED DERIVATIVES OF AROMATIC ETHERS

The present invention relates to the process for the preparation of halogenated derivatives of aromatic ethers.