- Synthesis of mono- and diaza-'pyridones' via stille coupling of alkoxystannanes
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Various alkoxy-substituted heterocyclic stannanes provide access to the corresponding substituted 'pyridone' moieties via Stille cross-coupling. Both pyridyl and a series of diazinyl stannanes are prepared, and options for unmasking (via demethylation or debenzylation) of the pyridone unit are evaluated. Georg Thieme Verlag Stuttgart. New York.
- Smith, Charlotte L.,Hirschh?user, Christoph,Malcolm, Georgia K.,Nasrallah, Daniel J.,Gallagher, Timothy
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p. 1904 - 1908
(2014/08/18)
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- Pd(II)-Catalyzed ortho-trifluoromethylation of arenes using TFA as a promoter
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"Chemical equation presented" A Pd(II)-catalyzed C-H activation/trifluoromethylation of arenes with an electrophilic trifluoromethylation reagent using diverse heterocycle directing groups is reported. The presence of trifluoroacetic acid is crucial for this catalytic reaction.
- Wang, Xisheng,Truesdale, Larry,Yu, Jin-Quan
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supporting information; experimental part
p. 3648 - 3649
(2010/05/15)
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- Microwave-assisted, efficient and regioselective Pd-catalyzed C-phenylation of halopyrimidines
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We herein report that flash heating microwave irradiation is a helpful tool in the formation of arylpyrimidines from the corresponding halopyrimidines. The palladium-catalyzed cross-coupling reactions of 2,4-di- and 2,4,5-trihalopyrimidines with phenylboronic acid under the above conditions are described. By use of the appropriate catalyst and the adequate halopyrimidine, good regioselectivity can be achieved in the 2-, 4-, or 5-positions of the heterocycle. In addition, we show that this methodology is ameneable for the stepwise preparation of mono-, di-, and triphenylpyrimidines.
- Ceide, Susana Conde,Montalban, Antonio Garrido
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p. 4415 - 4418
(2007/10/03)
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- Synthesis of new polyaza heterocycles. Part 42: Diazines
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Using Pd-catalyzed Stille cross-coupling reactions, we report here the synthesis of various mono- or bis(tri-n-butylstannyl)diazines which were reacted with various halogenated diazines to access to various polyaza heterocyclic derivatives.
- Darabantu, Mircea,Boully, Ludovic,Turck, Alain,Plé, Nelly
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p. 2897 - 2905
(2007/10/03)
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