Resolution of racemic 2-amino-1-butanol with immobilised penicillin G acylase
Racemic 2-amino-1-butanol has been resolved to obtain (S)-2-amino-1- butanol with >99% e.e. via enantioselective hydrolysis of its N-phenylacetyl derivative with penicillin G acylase immobilised on Eupergit C. (C) 1999 Elsevier Science Ltd.
Efficient continuous kinetic resolution of racemic 2-aminobutanol over immobilized penicillin G acylase
In this paper, an efficient method was established for continuous kinetic resolution of racemic 2-aminobutanol by selective hydrolysis of N-phenylacetyl (±)-2-aminobutanol over immobilized penicillin G acylase (PGA) in a fixed-bed reactor. Several N-acylated derivatives of 2-aminobutanol were screened in batch experiments, and it was found that the hydrolysis of N-phenylacetyl (±)-2-aminobutanol proceeded smoothly in the presence of immobilized penicillin G acylase with satisfied enantioselectivity. Thus, the reaction parameters were optimized in a fixed-bed reactor. Under the optimized conditions, 39.3% conversion of N-phenylacetyl (±)-2-aminobutanol and 98.2% ee value of S-2-aminobutanol were obtained. This fixed-bed system was operated continuously for 40?h without significant decrease of enzyme activity. It has been demonstrated to be more efficient compared to the batch experiments.
Wang, Jianxin,Liu, Na,Cheng, Xiaobo,Chen, Ligong
supporting information
p. 956 - 962
(2016/07/07)
Ammonium nitrate: A biodegradable and efficient catalyst for the direct amidation of esters under solvent-free conditions
A simple, metal-free, and environment-friendly procedure is developed for the direct conversion of esters to amides using ammonium nitrate as a catalyst under solvent-free conditions. Aryls, heteroaryls, and aliphatic esters are easily converted to the corresponding amides in excellent isolated yields (85-99%). An enantiopure ester and amine were both shown to react without racemization. The methodology has been successfully applied to preparation of procainamide.
Ramesh, Perla,Fadnavis, Nitin W.
supporting information
p. 138 - 140
(2015/02/19)
More Articles about upstream products of 34114-57-3