Design, synthesis and structure-activity relationship studies of morpholino-1H-phenalene derivatives that antagonize Mcl-1/Bcl-2
We report herein characteristic studies of Mcl-1 and Bcl-2 dual inhibitors. It was found that a protruding carbonyl group forming hydrogen bond with R263 plays a predominant role compared with the hydrophobic group that occupies the p2 pocket. A series of dual inhibitors representing different parts of the morpholino-1H-phenalene were designed, synthesized and evaluated.
Novel sulfanylphthalimide analogues as highly potent inhibitors of monoamine oxidase B
Monoamine oxidase (MAO) plays an essential role in the catabolism of neurotransmitter amines. The two isoforms of this enzyme, MAO-A and -B, are considered to be drug targets for the therapy of depression and neurodegenerative diseases, respectively. Base
Van Der Walt, Mietha M.,Terre'Blanche, Gisella,Petzer, Anél,Petzer, Jacobus P.
supporting information
p. 6632 - 6635
(2013/01/14)
PHTHALOCYANINES AND RELATED COMPOUNDS. XVIII. PHENOXY- AND (PHENYLTHIO)-SUBSTITUTED PHTHALOCYANINES
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Derkacheva, V. M.,Luk'yanets, E. A.
p. 1874 - 1878
(2007/10/02)
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