343223-65-4Relevant articles and documents
Design, synthesis and structure-activity relationship studies of morpholino-1H-phenalene derivatives that antagonize Mcl-1/Bcl-2
Li, Xiangqian,Liang, Xiaomeng,Song, Ting,Su, Pengchen,Zhang, Zhichao
, p. 5738 - 5746 (2015/02/02)
We report herein characteristic studies of Mcl-1 and Bcl-2 dual inhibitors. It was found that a protruding carbonyl group forming hydrogen bond with R263 plays a predominant role compared with the hydrophobic group that occupies the p2 pocket. A series of dual inhibitors representing different parts of the morpholino-1H-phenalene were designed, synthesized and evaluated.
PHTHALOCYANINES AND RELATED COMPOUNDS. XVIII. PHENOXY- AND (PHENYLTHIO)-SUBSTITUTED PHTHALOCYANINES
Derkacheva, V. M.,Luk'yanets, E. A.
, p. 1874 - 1878 (2007/10/02)
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