- Preparation process of pebiprofen
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The invention belongs to the field of chemistry, and particularly relates to a novel process for preparing a phenylpropionic acid non-steroidal anti-inflammatory drug pebiprofen. According to the invention, 2-(4-bromomethyl phenyl) propionic acid which is easy to obtain is used as a starting raw material, and the product is prepared by four steps of esterification, hydroformylation, condensation and hydrolysis reaction. The method has the characteristics of simplicity in operation, high reaction selectivity, few byproducts and high product quality.
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Paragraph 0029; 0036-0038; 0039; 0046-0047
(2021/07/24)
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- Methods of Preparing Pelubiprofen
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The present invention relates to a method for preparing pelubiprofen. According to the preparation method of the present invention, it is possible to prepare high-purity pelubiprofen in high yield, and a manufacturing process thereof is easy, economical, and eco-friendly. The present invention comprises a step of preparing a compound represented by chemical formula 1 by making a compound represented by chemical formula A-1 react with a compound represented by chemical formula B.COPYRIGHT KIPO 2020
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Paragraph 0081-0088
(2020/09/12)
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- Process for preparing anti-inflammatory cycloalkylidenemethylphenylacetic acid derivatives
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Cycloalkylidenemethylphenylacetic acid derivatives of formula (I): STR1 (wherein R1 represents hydrogen or alkyl and n is an integer from 1 to 3) are prepared by reacting a benzaldehyde acid compound of formula (II): STR2 with an enamine derivative of formula (III): STR3 (wherein R2 and R3 are various organic groups) and then hydrolizing the product. The use of the acid of formula (II) rather than its corresponding ester enables the reaction to be effected with a good yield and under moderate and economical reaction conditions.
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- Cycloalkylidenemethylphenylacetic acid derivatives and process for the preparation thereof
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Novel 4-(2-oxo-1-cycloalkylidenemethyl)phenylacetic acid derivatives and non-toxic pharmaceutically acceptable salts thereof are useful as anti-inflammatory agents. The compounds may be prepared by reacting a p-formylphenylacetic acid ester derivative
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