344338-25-6

Basic information

• Product Name: 2-4-[(2-oxo-cyclohexylidene)methyl]phenylpropionic acid
• Synonyms: 2-4-[(2-oxo-cyclohexylidene)methyl]phenylpropionic acid
• CAS NO: 344338-25-6
• Molecular Weight: 258.317
• Mol File: 344338-25-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-4-[(2-oxo-cyclohexylidene)methyl]phenylpropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-4-[(2-oxo-cyclohexylidene)methyl]phenylpropionic acid(344338-25-6)
• EPA Substance Registry System: 2-4-[(2-oxo-cyclohexylidene)methyl]phenylpropionic acid(344338-25-6)

Safety Data

• Hazardous Substances Data: 344338-25-6(Hazardous Substances Data)

Usage

Main properties

1. Name: 2-4-[(2-oxo-cyclohexylidene)methyl]phenylpropionic acid
2. Common name: Ketoprofen
3. Type: Nonsteroidal anti-inflammatory drug (NSAID)
4. Purpose: Used to relieve pain and inflammation

Specific content

1. Mechanism of action: Inhibits the production of prostaglandins
2. Common uses: Treat conditions such as arthritis, menstrual cramps, and minor injuries
3. Available forms: Oral tablets, capsules, topical creams
4. Potential side effects: Stomach ulcers, bleeding, allergic reactions
5. Important considerations: Use only as prescribed by a healthcare professional; monitor closely for adverse effects

Upstream product

• 99807-54-2 2-(4-bromomethylphenyl)propionic acid methyl ester 
• 111128-12-2 2-[4-(bromomethyl)phenyl]propanoic acid 
• 43153-07-7 2-(4-formylphenyl)propanoic acid 
• 108-94-1 cyclohexanone 
• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 
• 69956-74-7 ethyl 2-[4-(2-oxo-1-cyclohexylidenemethyl)phenyl]propionate 

Relevant articles and documents

Preparation process of pebiprofen

The invention belongs to the field of chemistry, and particularly relates to a novel process for preparing a phenylpropionic acid non-steroidal anti-inflammatory drug pebiprofen. According to the invention, 2-(4-bromomethyl phenyl) propionic acid which is easy to obtain is used as a starting raw material, and the product is prepared by four steps of esterification, hydroformylation, condensation and hydrolysis reaction. The method has the characteristics of simplicity in operation, high reaction selectivity, few byproducts and high product quality.

Process for preparing anti-inflammatory cycloalkylidenemethylphenylacetic acid derivatives

Cycloalkylidenemethylphenylacetic acid derivatives of formula (I): STR1 (wherein R1 represents hydrogen or alkyl and n is an integer from 1 to 3) are prepared by reacting a benzaldehyde acid compound of formula (II): STR2 with an enamine derivative of formula (III): STR3 (wherein R2 and R3 are various organic groups) and then hydrolizing the product. The use of the acid of formula (II) rather than its corresponding ester enables the reaction to be effected with a good yield and under moderate and economical reaction conditions.