- Hypolipidemic activity of 6-substituted 6,7-dihydro-5H-dibenz[c,e]azepine and the effects of 6,7-dihydro-5H-dibenz[c,e]azepine on lipid metabolism of rodents
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A series of 6-substituted derivatives of 6,7-dihydro-5H-dibenz[c,e]azepine was found to be active hypolipidemic agents in rodents at doses of mg/kg per day. The parent drug was found to suppress the enzyme activity of ATP-dependent citrate lyase, sn-glyce
- Hall,Murthy,Wyrick
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- A facile synthesis of 6-alkyl-6,7-dihydro-5H-dibenz[c,e]azepines: Potent hypolipidemics
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6-Alkyl-6,7-dihydro-5H-dibenz[c,e]azepines were synthesized in two steps in 63-88% overall yield by utilizing an efficient borane-tetrahydrofuran reduction of imides.
- Akula,Kabalka
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- An amine template strategy to construct successive C-C bonds: Synthesis of benzo[: H] quinolines by a deaminative ring contraction cascade
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We developed a convergent strategy to build, cyclize and excise nitrogen from tertiary amines for the synthesis of polyheterocyclic aromatics. Biaryl-linked azepine intermediates can undergo a deaminative ring contraction cascade reaction, excising nitrogen with the formation of an aromatic core. This strategy and deaminative ring contraction reaction are useful for the synthesis of benzo[h]quinolines. This journal is
- McFadden, Timothy Patrick,Nwachukwu, Chideraa Iheanyi,Roberts, Andrew George
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p. 1379 - 1385
(2022/03/01)
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- Reductive cleavage of benzannelated cyclic ethers and amines: Synthetic applications
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Reduction of symmetrical intramolecular diarylmethyl ethers (3a and 8a) and amines (3b and 8b) with alkali metals in THF allows the generation of unsymmetrical oxy- or amino-functionalised arylmethyl organometallics. Such intermediates were successfully trapped with various electrophiles, allowing a new access to unsymmetrically 2,2'-disubstituted-1,1'-biaryls (5aa-5bf) and 1,8-disubstituted naphthalenes (10aa-10be). (C) 2000 Elsevier Science Ltd.
- Azzena, Ugo,Demartis, Salvatore,Pilo, Luciano,Piras, Elisabetta
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p. 8375 - 8382
(2007/10/03)
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- 1,7-Electrocyclisation of non-stabilised α,β:y,o-unsaturated azomethine ylides
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The generation of α,β:γ,5-unsaturated azomethine ylides 8 is described, starting from TV-substituted α-amino acids 7 and aldehydes 6,12. These azomethine ylides undergo a 1,7-electrocyclisation, followed by a [l,5]-hydrogen shift, to give the dihydrobenza
- Arany, Andrea,Bendell, David,Groundwater, Paul W.,Garnett, Ian,Nyerges, Miklos
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p. 2605 - 2608
(2007/10/03)
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