- METHODS OF REJUVENATING AGED TISSUE BY INHIBITING 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE (15-PGDH)
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The present disclosure provides compositions and methods based on the identification of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as a therapeutic target in aging, dystrophic muscle to improve muscle atrophy, increase muscle mass, function and strength. Further provided herein are compositions and methods for the rejuvenation of aged tissue. In particular, 15-PGDH inhibitors, such as SW033291, are used to elevate the levels of prostaglandin E2 (PGE2) in the muscle or tissue.
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Paragraph 0029; 0036; 0055
(2020/12/30)
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- A simple and efficient synthesis of the front row element of the method
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The invention provides a method for simply and efficiently synthesizing dinoprost. The method comprises synthesis steps as follows: L-corey lactone diol is selectively oxidized to aldehyde-containingcorey lactone monols, namely, a compound I; the compound I and dimethyl(2-oxoheptyl)phosphonate are subjected to a Honel-Wadsworth-Emmons reaction, and a reactive product compound II is produced; lactone is reduced to alcohol, and an intermediate, namely, a compound III, is obtained; the intermediate III selectively oxidizes primary alcohol, and an intermediate, namely, a compound IV, is obtained;the compound IV is subjected to a Witting reaction, and the dinoprost is produced. According to the method for simply and efficiently synthesizing dinoprost, raw materials are simple and easy to obtain, and equipment requirements are simple; the steps are short, and industrial production is easy to realize; no heavy metals or other strong carcinogens are used in the whole process; an intermediatepurification method is simple and impurities are easy to control.
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Paragraph 0030; 0069; 0070
(2018/12/02)
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- Endoperoxide pathway in prostaglandin biosynthesis in the soft coral Gersemia fruticosa
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An acetone powder preparation of the White Sea soft coral Gersemia converts exogenous arachidonic acid to a prostaglandin-endoperoxide, identified as PGG2 by chemical and spectral studies. The latter serves as a key intermediate from which, evidently by nonenzymic transformations, all optically active coral prostaglandins are formed.
- Varvas, Kuelliki,Koljak, Reet,Jaerving, Ivar,Pehk, Tonis,Samel, Nigulas
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p. 8267 - 8270
(2007/10/02)
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- STEREOSPECIFIC NITROMETHANE CONJUGATE ADDITION TO 4-OXYGENATED-2-SUBSTITUTED-CYCLOPENT-2-ENONES: A SIMPLE APPROACH TO PROSTAGLANDINS
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The compatibility of nitromethane conjugate addition to 2-cyclopentenones bearing a 4-oxygenated function has been illustrated through a short and practical synthesis of the Corey aldehyde, a key intermediate in prostaglandin synthesis, in both racemic and optically active form.A new synthesis of PGF2α featuring the introduction of the ω-chain via cycloaddition has been also described.
- Baraldi, P. G.,Barco, A.,Benetti, S.,Pollini, G. P.,Simoni, D.,Zanirato, V.
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p. 4669 - 4678
(2007/10/02)
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