35850-13-6 Usage
Description
15-Keto Prostaglandin F2α (15-keto PGF2α) is the first metabolite of PGF2α in the 15-hydroxy PGDH pathway. It is a critical component in the postovulatory pheromone of goldfish and Atlantic salmon, playing a significant role in stimulating the olfactory receptors of male goldfish and salmon. Although it is 10-fold less active than PGF2α in decreasing rabbit intraocular pressure, 15-keto PGF2α is an essential quantitative grade standard for mass spectrometry and applications requiring quantitative reproducibility.
Uses
Used in Aquatic Biology and Reproduction Studies:
15-Keto Prostaglandin F2α is used as a pheromone component for promoting reproductive behavior in goldfish and Atlantic salmon. It stimulates the male olfactory receptors, with detection thresholds of 10^-12 and 10^-8 M for goldfish and salmon, respectively, facilitating mating and reproduction in these species.
Used in Ophthalmology Research:
15-Keto Prostaglandin F2α is used as a comparative compound in the study of intraocular pressure in rabbits. Its 10-fold lower activity compared to PGF2α makes it a valuable reference for understanding the effects of prostaglandins on ocular pressure and potential therapeutic applications.
Used in Mass Spectrometry and Quantitative Analysis:
15-Keto Prostaglandin F2α is used as a quantitative grade standard in mass spectrometry and other applications requiring high precision and reproducibility. The MaxSpec standard ensures identity, purity, stability, and concentration specifications, making it an essential tool for accurate measurements and analysis in various research and diagnostic settings.
Used in Pharmaceutical and Biomedical Research:
15-Keto Prostaglandin F2α is used as a research compound for investigating the biological activities and potential therapeutic applications of prostaglandins. Its unique properties and interactions with olfactory receptors make it a valuable asset in the development of new drugs and therapies targeting various physiological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 35850-13-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,8,5 and 0 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 35850-13:
(7*3)+(6*5)+(5*8)+(4*5)+(3*0)+(2*1)+(1*3)=116
116 % 10 = 6
So 35850-13-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,16-19,22-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t16-,17-,18+,19-/m1/s1
35850-13-6Relevant articles and documents
METHODS OF REJUVENATING AGED TISSUE BY INHIBITING 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE (15-PGDH)
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Paragraph 0029; 0036; 0055, (2020/12/30)
The present disclosure provides compositions and methods based on the identification of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as a therapeutic target in aging, dystrophic muscle to improve muscle atrophy, increase muscle mass, function and strength. Further provided herein are compositions and methods for the rejuvenation of aged tissue. In particular, 15-PGDH inhibitors, such as SW033291, are used to elevate the levels of prostaglandin E2 (PGE2) in the muscle or tissue.
Endoperoxide pathway in prostaglandin biosynthesis in the soft coral Gersemia fruticosa
Varvas, Kuelliki,Koljak, Reet,Jaerving, Ivar,Pehk, Tonis,Samel, Nigulas
, p. 8267 - 8270 (2007/10/02)
An acetone powder preparation of the White Sea soft coral Gersemia converts exogenous arachidonic acid to a prostaglandin-endoperoxide, identified as PGG2 by chemical and spectral studies. The latter serves as a key intermediate from which, evidently by nonenzymic transformations, all optically active coral prostaglandins are formed.
Isolation of a new naturally occurring prostaglandin, 5-trans-PGA 2 . Synthesis of 5-trans-PGE 2 and 5-trans-PGF 2a .
Bundy,Daniels,Lincoln,Pike
, p. 2124 - 2124 (2007/10/06)
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