- Direct Synthesis of Enamides via Electrophilic Activation of Amides
-
A novel, one-step N-dehydrogenation of amides to enamides is reported. This reaction employs the unlikely combination of LiHMDS and triflic anhydride, which serves as both the electrophilic activator and the oxidant, and is characterized by its simple setup and broad substrate scope. The synthetic utility of the formed enamides was readily demonstrated in a range of downstream transformations.
- Berger, Martin,Kaiser, Daniel,Maulide, Nuno,Spie?, Philipp
-
supporting information
p. 10524 - 10529
(2021/07/28)
-
- In situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes
-
An environmentally friendly synthetic route by the application of CO2 to synthesize amides via in situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes was developed. Various secondary and tertiary amides have been synthesized in moderate to good yields under mild and neutral reaction conditions. The use of amine hydrochloride salts and hence base for neutralization step is totally avoided in this protocol.
- Bathini, Thulasiram,Rawat, Vikas S.,Bojja, Sreedhar
-
supporting information
p. 5656 - 5660
(2015/09/15)
-
- N2 extrusion and co insertion: A novel palladium-catalyzed carbonylative transformation of aryltriazenes
-
A novel procedure for the replacement of N2 with CO of aryltriazenes has been developed. Aryltriazenes were converted to the corresponding arylamides catalyzed by 1 mol % of PdCl2/P(o-Tol)3 under CO pressure. In this process, aryldiazonium salts were generated in the presence of 40 mol % of MeSO3H. Nitrogen was released from the substrates and CO formally inserted. Aryl bromides, iodides, alkynes, and free hydroxyl groups can be tolerated in this transformation.
- Li, Wanfang,Wu, Xiao-Feng
-
supporting information
p. 1910 - 1913
(2015/04/27)
-
- Synthesis and CNS-depressant profile of 3,4,5-trimethoxybenzoyl analogues
-
A series of 3,4,5-trimethoxybenzoyl analogues with varying electronic and stereochemical characteristics has been synthesized. Many of these compounds (4, 5, 9, 12, 15) showed appreciable potentiation of pentobarbitone-induced hypnosis. Several analogues (1, 5, 6, 11, 12, 15) exhibited marked reduction of spontaneous motor activity (SMA).
- Kar
-
p. 313 - 315
(2007/10/02)
-