- Stereocontrolled synthesis of 1,2-dialkyl-4-halopyrrolidines through PhSeX-induced cyclization of secondary homoallylamines
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The selenium-induced cyclization of α-alkyl or α,α-dialkylhomoallyl-benzylamines 1 by use of PhSeX (X = Cl, Br, I; 1.5 equiv.) provided a mixture of (phenylselanylmethyl)azetidines 2 and (phenylselanyl)pyrrolidines 3.[1] When an excess of PhSeX (X = Cl, Br) was used, 4-halopyrrolidines 4 (X = Cl) or 5 (X = Br) were formed and isolated in very good yields. Mono- or dialkyl 4-halopyrrolidines 4 and 5 could also be obtained stereospecifically by SO2Cl2 or Br2 treatment of 4-(phenylselanylmethyl)azetidines 2, by way of the intermediate (halomethyl)azetidines 14 (X = Cl) or 15 (X = Br). When starting from 4-(phenylselanyl)pyrrolidines 3, monoalkylated 4-halopyrrolidines 4 or 5 could be obtained stereospecifically after decomposition of the unstable dihaloselenuranes 16 and 17. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.
- Outurquin, Francis,Pannecoucke, Xavier,Berthe, Benedicte,Paulmier, Claude
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p. 1007 - 1014
(2007/10/03)
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- Synthesis of Functionalized Pyrrolidines from N-(Benzylidene)- and N-(Alkylidene)-homoallylamines
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N-(Benzylidene)- and N-(alkylidene)-homoallylamines are cyclised by electrophiles, e.g. bromine or phenylselenenyl bromide, and by subsequent reduction to the corresponding 3-functionalised pyrrolidines; the stereochemistry was investigated, and reductive
- Smaele Dirk De,Kimpe, Norbert De
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p. 2029 - 2030
(2007/10/02)
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