- Discovery of SMP-304, a novel benzylpiperidine derivative with serotonin transporter inhibitory activity and 5-HT1Aweak partial agonistic activity showing the antidepressant-like effect
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We report the discovery of a novel benzylpiperidine derivative with serotonin transporter (SERT) inhibitory activity and 5-HT1Areceptor weak partial agonistic activity showing the antidepressant-like effect. The 3-methoxyphenyl group and the ph
- Yoshinaga, Hidefumi,Masumoto, Shuji,Koyama, Koji,Kinomura, Naoya,Matsumoto, Yuji,Kato, Taro,Baba, Satoko,Matsumoto, Kenji,Horisawa, Tomoko,Oki, Hitomi,Yabuuchi, Kazuki,Kodo, Toru
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p. 293 - 304
(2016/12/22)
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- Serotonin reuptake inhibitor
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A serotonin reuptake inhibitor containing a cyclic amine represented by the following formula, a prodrug thereof, or a pharmaceutically acceptable salt of said cyclic amine or prodrug as an active ingredient: wherein R0 is a hydrogen atom, a halogen atom, an alkyl group, a substituted alkyl group, a hydroxyl group, an alkoxy group or the like, R3 is a hydrogen atom or the like, Y is an alkylene group or the like, Z is a hydrogen atom, a cycloalkyl group, an aryl group or the like, n is 1, 2 or 3, and m is 2, 3, 4, 5 or 6.
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