- Sulfur-containing andrographolide derivative and pharmaceutical composition and synthesis method thereof and application of sulfur-containing andrographolide derivative in preparation of medicine for treating prostatic cancers
-
The invention relates to an andrographolide derivative shown in the following general formula (I) or general formula (II) (please see the formula in the description) and a preparation method thereof and a composition containing the compound shown in the g
- -
-
Paragraph 0028; 0029
(2017/03/25)
-
- Synthesis of thioether andrographolide derivatives and their inhibitory effect against cancer cells
-
A series of novel thioether andrographolide derivatives were synthesized by incorporating various aromatic (or heteroaromatic) substituents into C-12 or 14-OH. A total of 38 andrographolide derivatives were prepared and evaluated for their in vitro inhibi
- Liu, Yi,Liang, Ren-Ming,Ma, Qing-Ping,Xu, Kai,Liang, Xin-Yong,Huang, Wei,Sutton, Robert,Ding, Jie,O'Neil, Paul M.,Cheng, Chun-Ru
-
supporting information
p. 1268 - 1274
(2017/07/07)
-
- Nonmetal catalyzed insertion reactions of diazocarbonyls to acid derivatives in fluorinated alcohols
-
The insertion reaction of diazocarbonyls to acids could be performed smoothly in fluorinated alcohols in the absence of metal catalyst. This new procedure allowed the chemoselective preparation of various functionalized compounds such as acyloxyesters, depsipeptides, and sulfonate, phosphonate, or boronate derivatives.
- Dumitrescu, Lidia,Azzouzi-Zriba, Kaouther,Bonnet-Delpon, Daniele,Crousse, Benoit
-
supporting information; experimental part
p. 692 - 695
(2011/04/24)
-
- Synthesis of [11C]PBR06 and [18F]PBR06 as agents for positron emission tomographic (PET) imaging of the translocator protein (TSPO)
-
The translocator protein 18 kDa (TSPO) is an attractive target for molecular imaging of neuroinflammation and tumor progression. [ 18F]PBR06, a fluorine-18 labeled form of PBR06, is a promising PET TSPO radioligand originally developed at NIMH.
- Wang, Min,Gao, Mingzhang,Miller, Kathy D.,Zheng, Qi-Huang
-
experimental part
p. 1331 - 1340
(2011/11/06)
-
- SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY
-
The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization, Stat3-DNA binding, Stat5-DNA binding, and/or aberrant cell growthinvitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The compounds of the invention include, but are not limited to, NSC 74859 (S3I-201), NSC 42067, NSC 59263, NSC 75912, NSC 11421, NSC 91529, NSC 263435, and pharmaceutically acceptable salts and analogs of the foregoing. Other non-malignant diseases characterized by proliferation of cells that may be treated using the compounds of the invention, but are not limited to, cirrhosis of the liver; graft rejection; restenosis; and disorders characterized by a proliferation of T cells such as autoimmune diseases, e.g., type 1 diabetes, lupus and multiple sclerosis. The invention further includes an in-vitro screening test for the presence of malignant cells in a mammalian tissue; a method of identifying inhibitors of constitutive Stat3 activation, Stat3-DNA binding, Stat5-DNA binding, and/or Stat3 dimerization; and a method of identifying anti-cancer agents.
- -
-
Page/Page column 62
(2008/06/13)
-
- Synthesis of no-carrier-added [18F]fluoroacetate
-
To synthesize no-carrier-added potassium [18F]fluoroacetate, O-mesyl glycolate ethyl ester and O-tosyl glycolate ethyl ester were synthesized as precursors. These precursors were radiolabeled by reacting with dried tetrabutylammonium [18/
- Jeong, Jae Min,Lee, Dong Soo,Chung, June-Key,Lee, Myung Chul,Koh, Chang-Soon,Kang, Sam Sik
-
p. 395 - 399
(2007/10/03)
-
- Reaction of Carbenes with Cyclic Ethers in the Presence of Nucleophiles. A Three-Component Coupling Reaction
-
Ternary reaction systems consisting of a carbene , a cyclic ether (THF, THP) and a protic nucleophile (alcohol, water, carboxylic acid, thiol, or amine) give the corresponding three-component coupling products which are produced via ethereal oxonium ylide intermediates.The mechanism leading to the product formation has been studied in which protonation of carbenes is excluded.
- Oku, Akira,Kimura, Kenji,Ohwaki, Shigeyoshi
-
p. 391 - 397
(2007/10/02)
-
