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40627-30-3

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NUCLEOSIDE ANALOGUES FOR THE TREATMENT OF PARASITIC INFECTIONS
The present invention relates to novel nucleoside analogues and compositions containing said nucleoside analogues. Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the diagnosis, prevention and/or treatment of parasitic infections, more specifically for use in the diagnosis, prevention and/or treatment of a Trypanosoma infection.
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Page/Page column 37

(2019/05/10)

The Use of Heterocyclic Chemistry in the Synthesis of Natural and Unnatural Products
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Confalone, Pat. N.
p. 31 - 46
(2007/10/02)

Synthesis of 2',3'-didehydro-2',3'-didoxyformycin A, 2',3'-Dideoxyformycin A and 2',3'-Dideoxytubercidin
2',3'-Didehydro-2',3'-dideoxyformycin A (7) was prepared by reaction of the 7-amino-3-[5-O-(2-acetoxyisobutyryl)-3-bromo-3-deoxy-2-O- phenoxy(thiocarbonyl)-β-D-xylofuranosyl]-1 H-pyrazolo [4,3-d]-pyrimidine (5) or 7-amino-3-[5-O-(2-acetoxyisobutyryl)-2- bromo-2-deoxy-3-O-phenoxy(thiocarbonyl)-β-D-arabinofuranosyl]-1 H-pyrazolo[4,3-d]pyrimidine (9) with tributyltin hydride and subsequent deprotection of the resulting 5'-O-(2-acetoxyisobutyryl)-2',3'-didehydro-2',3'-dideoxyformycin A (6). 2',3'-Dideoxyformycin A (13) and 2',3'-dideoxytubercidin (16) were synthesized via deoxygeneration of their respective 3'-deoxy counterparts 10 and 2, respectively.
Serafinowski
p. 411 - 415
(2007/10/02)

Synthesis of 6-substituted 7-carbapurine 2',3'-dideoxynucleosides: Solid-liquid phase-transfer glycosylation of 4-chloropyrrolo[2,3-d]pyrimidine and deoxygenation of its 2'-deoxyribofuranoside
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Seela,Muth,Bindig
p. 670 - 674
(2007/10/02)

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Chemical Properties

Boiling Point: 517.3°Cat760mmHg
Flash Point:266.7°C
Density: 1.61g/cm³
Vapor Pressure: 1.58E-11mmHg at 25°C
Refractive Index: 1.762
PKA: 14.44±0.10(Predicted)
PSA: 86.19000
LogP: 1.26460

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