40627-30-3

Basic information

• Product Name: 7-Deaza-2,3-dideoxyadenosine Suppliers
• Synonyms: 7-Deaza-2,3-dideoxyadenosine Suppliers;7-Deaza-ddA;7-ap-7-ddATP;(2S,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-2-furanmethanol;2',3'-Dideoxy tubercidin;2',3'-Dideoxy tubercidin
• CAS NO: 40627-30-3
• Molecular Formula: C₁₁H₁₄N₄O₂
• Molecular Weight: 234.25446
• Mol File: 40627-30-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 517.3°Cat760mmHg
• Flash Point: 266.7°C
• Appearance: /
• Density: 1.61g/cm³
• Vapor Pressure: 1.58E-11mmHg at 25°C
• Refractive Index: 1.762
• PKA: 14.44±0.10(Predicted)
• CAS DataBase Reference: 7-Deaza-2,3-dideoxyadenosine Suppliers(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Deaza-2,3-dideoxyadenosine Suppliers(40627-30-3)
• EPA Substance Registry System: 7-Deaza-2,3-dideoxyadenosine Suppliers(40627-30-3)

Safety Data

• Hazardous Substances Data: 40627-30-3(Hazardous Substances Data)

Usage

General Description

7-Deaza-2,3-dideoxyadenosine, also known as tubercidin, is a chemical compound commonly used in scientific research for its antiviral and antitumor properties. It is a nucleoside analog that inhibits RNA synthesis and has shown potential in the treatment of various viral infections, including HIV and herpes. 7-Deaza-2,3-dideoxyadenosine suppliers provide this compound for research and development purposes, offering high-quality and pure forms of the chemical to researchers and pharmaceutical companies. These suppliers ensure the availability of 7-Deaza-2,3-dideoxyadenosine in bulk quantities and provide technical support to their customers for its efficient and safe use in their studies and experiments.

InChI:InChI=1/C11H14N4O2/c12-10-8-3-4-15(11(8)14-6-13-10)9-2-1-7(5-16)17-9/h3-4,6-7,9,16H,1-2,5H2,(H2,12,13,14)/t7-,9+/m0/s1

Upstream product

• 69-33-0 tubercidin 
• 115899-25-7 2-Acetoxy-2-methyl-propionic acid (2R,3S,4S,5R)-4-acetoxy-5-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-3-bromo-tetrahydro-furan-2-ylmethyl ester 
• 40725-89-1 4-amino-N7-(3'-deoxy-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine 
• 128878-82-0 4-amino-7-<3-deoxy-5-O-4-methoxytrityl-2-O-phenoxy(thiocarbonyl)-β-D-ribofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine 
• 128878-76-2 4-amino-7-<3-deoxy-5-O-(4-methoxytrityl)-β-D-ribofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine 
• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 
• 119447-94-8 4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-3'-O-phenoxythiocarbonyl-7H-pyrrolo<2,3-d>pyrimidine 
• 119447-93-7 4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-7H-pyrrolo<2,3-d>pyrimidine 
• 119447-95-9 4-Chloro-7-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-5'-O-(4,4'-dimethoxytrityl)-7H-pyrrolo<2,3-d>pyrimidine 
• 91713-43-8 4-chloro-7-<2'-deoxy-3',5'-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>pyrimidine 
• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 97337-37-6 4-chloro-7-<2-deoxy-β-D-erythro-pentofuranosyl>-7H-pyrrolo<2,3-d>-pyrimidine 
• 64702-16-5 7-(2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl)-7H-pyrrolo<2,3-d>pyrimidin-4-amine 
• 135885-06-2 7-{(2R,5S)-5-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine 

Downstream Products

• 114748-69-5 C₁₄H₂₀N₅O₁₁P₃ 
• 114748-71-9 7-deaza-2',3'-dideoxy-7-(3-trifluoroacetamidopropyn-1-yl)adenosine 
• 114748-70-8 7-deaza-2',3'-dideoxy-7-iodoadenosine 
• 135093-00-4 Phosphoric acid mono-[(2S,5R)-5-(4-amino-pyrrolo[2,3-d]pyrimidin-7-yl)-tetrahydro-furan-2-ylmethyl] ester; compound with triethyl-amine 
• 135092-96-5 C₁₁H₁₇N₄O₁₁P₃*4C₆H₁₅N 

Relevant articles and documents

NUCLEOSIDE ANALOGUES FOR THE TREATMENT OF PARASITIC INFECTIONS

The present invention relates to novel nucleoside analogues and compositions containing said nucleoside analogues. Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the diagnosis, prevention and/or treatment of parasitic infections, more specifically for use in the diagnosis, prevention and/or treatment of a Trypanosoma infection.

Synthesis of 2',3'-didehydro-2',3'-didoxyformycin A, 2',3'-Dideoxyformycin A and 2',3'-Dideoxytubercidin

2',3'-Didehydro-2',3'-dideoxyformycin A (7) was prepared by reaction of the 7-amino-3-[5-O-(2-acetoxyisobutyryl)-3-bromo-3-deoxy-2-O- phenoxy(thiocarbonyl)-β-D-xylofuranosyl]-1 H-pyrazolo [4,3-d]-pyrimidine (5) or 7-amino-3-[5-O-(2-acetoxyisobutyryl)-2- bromo-2-deoxy-3-O-phenoxy(thiocarbonyl)-β-D-arabinofuranosyl]-1 H-pyrazolo[4,3-d]pyrimidine (9) with tributyltin hydride and subsequent deprotection of the resulting 5'-O-(2-acetoxyisobutyryl)-2',3'-didehydro-2',3'-dideoxyformycin A (6). 2',3'-Dideoxyformycin A (13) and 2',3'-dideoxytubercidin (16) were synthesized via deoxygeneration of their respective 3'-deoxy counterparts 10 and 2, respectively.